| Formulary Chapter 13: Skin - Full Chapter
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| Chapter Links... |
LSCMMG: Guidelines for the Management of Psoriasis in Primary Care |
LSCMMG: Position Statement: Prescribing of Medical Camouflaging Products |
LSCMMG: Psoriasis in adults: LSCMMG Biologic and High Cost Drug Commissioning Pathway |
NICE CG153: Psoriasis: assessment and management |
NICE CG57: Atopic eczema in under 12s: diagnosis and management |
NICE NG12: Suspected cancer: recognition and referral |
NICE NG14: Melanoma: assessment and management |
NICE NG198: Acne vulgaris: management |
| Details... |
| 13.01 |
Management of skin conditions |
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Birch bark extract (Filsuvez Gel®)
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Formulary

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Gel 100mg/1g
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NICE HST28: Birch bark extract for treating epidermolysis bullosa
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HidraWear
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Formulary
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Hidradenitis Suppurativa
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LSCMMG: HidraWear Position Statement
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| 13.01.01 |
Vehicles |
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| 13.01.02 |
Suitable quantities for prescribing |
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| 13.01.03 |
Excipients and sensitisation |
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| 13.02 |
Emollient and barrier preparations |
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| 13.02.01 |
Emollients |
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MHRA: Risk of severe and fatal burns with paraffin-containing and paraffin-free emollients
Advise patients who use these products not to smoke or go near naked flames, and warn about the easy ignition of clothing, bedding, dressings, and other fabric that have dried residue of an emollient product on them.
Emollient bath and shower preparations are no longer recommended. Most emollients can be used as a soap substitute. |
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Emulsifying Ointment BP
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Formulary
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Ointment
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Epimax®
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Formulary
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Cream Oatmeal cream Ointment Isomol gel Excetra cream
Do not prescribe Epimax® ointment for use on the face.
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MHRA: Epimax Ointment and Epimax Paraffin-Free Ointment: reports of ocular surface toxicity and ocular chemical injury
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Hydromol
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Formulary
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Ointment
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Liquid and White Soft Paraffin Ointment (50:50)
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Formulary
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Ointment
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Oilatum®
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Formulary
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Cream
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ZeroAQS®
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Formulary
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Aqueous cream, sodium lauryl sulfate free.
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| 13.02.01 |
Emollients - with antimicrobials |
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Dermol®
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Formulary
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Cream Lotion
Contains antimicrobials.
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| 13.02.01 |
Preparations containing urea |
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Balneum® plus
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Formulary
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Cream
Prescribing restricted to the treatment of CKD-associated Pruritus, in line with the Enhanced Supportive Kidney Care Guideline.
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Emollients containing urea
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Formulary
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Cream 10% (Flexitol®)
Cream 10% (Hydromol® Intensive)
Heel balm 25% (Flexitol®) - Use restricted to diabetic patient's only
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ImuDERM®
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Formulary
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Emollient 5%
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| 13.02.01.01 |
Emollient bath and shower preparations |
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| 13.02.02 |
Barrier preparations |
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Conotrane®
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Formulary
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Cream
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Medi Derma-S
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Formulary
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Spray barrier film
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Metanium®
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Formulary
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Ointment
Paediatric use only. Tissue viability nurse authorisation required for use in adult patients.
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Proshield Plus®
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Formulary
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Ointment
For excoriated skin.
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Sorbaderm®
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Formulary
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Cream
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Sudocrem®
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Formulary
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Cream For paediatric use only.
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| 13.03 |
Topical local anaesthetics and antipruritics |
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Also see chapter 15.02 Local anaesthesia. |
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Crotamiton (Eurax®)
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Formulary
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Cream 10%
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Levomenthol
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Formulary
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Cream 0.5%, 1%, 2%, 5%
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Difelikefalin (Kapruvia®)
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Formulary

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Solution for injection 50micrograms/mL
Under expert supervision.
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NICE TA890: Difelikefalin for treating pruritus in people having haemodialysis
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| 13.04 |
Topical corticosteroids. |
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In the BNF publications topical corticosteroids for the skin are categorised as ‘mild’, ‘moderately potent’, ‘potent’ or ‘very potent’; the least potent preparation which is effective should be chosen but dilution should be avoided whenever possible.
Potency of a topical corticosteroid preparation (including compound preparations) is based solely on the corticosteroid component, irrespective of the formulation and strength.
The potency of each topical corticosteroid should be included on the label with the directions for use. The label should be attached to the container (for example, the tube) rather than the outer packaging.
For guidance on quantities to prescribe see BNF: https://bnf.nice.org.uk/treatment-summaries/topical-corticosteroids/ |
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Hydrocortisone
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Formulary
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Cream 1% Ointment 1%
Consider OTC/Self care.
Mild corticosteroid.
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Hydrocortisone with clotrimazole (Canesten HC®)
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Formulary
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Cream hydrocortisone 1%, clotrimazole 1%
Consider OTC/Self care.
Mild corticosteroid.
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Hydrocortisone with fusidic acid (Fucidin H®)
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Formulary
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Cream hydrocortisone acetate 1%, fusidic Acid 2% Preparations containing fusidic acid should not be used in secondary care for in-patients.
Mild corticosteroid.
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Hydrocortisone with benzalkonium chloride, dimeticone and nystatin (Timodine®)
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Formulary
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Cream hydrocortisone 0.5%, nystatin 100000 unit per 1 g, benzalkonium chloride 0.2%, dimeticone '350' 10%
Mild corticosteroid.
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Hydrocortisone butyrate (Locoid®)
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Formulary
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Lipocream 0.1%
Lichen sclerosus in women when betamethasone cream is ineffective.
Moderate corticosteroid.
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Clobetasone Butyrate
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Formulary
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Cream 0.05% (Eumovate®) Ointment 0.05%
Moderate corticosteroid.
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Clobetasone butyrate with nystatin and oxytetracycline (Trimovate®)
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Formulary
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Cream clobetasone 0.05%, nystatin 100000 unit per 1 gram, oxytetracycline 3%
Moderate corticosteroid.
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Betamethasone Valerate
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Formulary
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Cream 0.025%, 0.1% Ointment 0.025%, 0.1% Scalp application 0.1% Foam 0.1% (Bettamousse®)
Potent corticosteroid.
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Betamethasone dipropionate with salicylic acid (Diprosalic®)
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Formulary
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Ointment betamethasone 0.05%, salicylic acid 3% Scalp application betamethasone 0.05%, salicylic acid 2%
Potent corticosteroid.
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Betamethasone valerate with fusidic acid
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Formulary
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Cream betamethasone 0.1%, fusidic acid 2% Preparations containing fusidic acid should not be used in secondary care for in-patients.
Potent corticosteroid.
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Betamethasone dipropionate with clotrimazole (Lotriderm®)
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Formulary
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Cream betamethasone 0.064% , clotrimazole 1%
Potent corticosteroid.
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Flucinolone Acetonide
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Formulary
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Gel 0.025% (Synalar®) For scalp use only.
Potent corticosteroid.
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Fludroxycortide
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Formulary
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Tape 4micrograms/square cm, 7.5cm
Potent corticosteroid.
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Mometasone Furoate
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Formulary
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Cream 0.1% Ointment 0.1%
Potent corticosteroid.
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Clobetasol Propionate
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Formulary
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Cream 0.05%, Ointment 0.05%
Cutaneous foam 0.05% (Clarelux®)
Shampoo 0.05% (Etrivex®)
Very potent corticosteroid.
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Betamethasone dipropionate (Diprosone®)
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Formulary
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Cream 0.05%
For use post urology surgery.
Potent corticosteroid.
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| 13.04 |
Topical corticosteriod preparation potencies |
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| 13.04 |
Topical corticosteroids (Potency: Mild) |
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| 13.04 |
Topical corticosteroids (Potency: Moderate) |
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| 13.04 |
Topical corticosteroids (Potency: Potent) |
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| 13.04 |
Topical corticosteroids (Potency: Very Potent) |
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| 13.04.01 |
Topical corticosteroids – Compound preparations – with antimicrobials |
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| 13.04.01 |
Topical corticosteroids – Compound preparations – with salicyclic acid |
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| 13.05 |
Preparations for eczema and psoriasis |
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| 13.05.01 |
Preparations for eczema |
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Alitretinoin (Prescribe generically)
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Formulary

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Capsules 10mg, 30mg Prescribed by or under supervision of a consultant dermatologist.
Contra-indicated in patients with hypersensitivity to peanuts or soya (capsule filling contains soya-bean oil).
Neuropsychiatric reactions have been reported in patients taking oral retinoids. The MHRA advises patients and carers to seek medical attention if changes in mood or behaviour occur.
Patients should avoid excessive exposure to UV light (including sunlight, solariums)—sunscreen with a high protection factor should be applied.
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MHRA: Oral retinoids: pregnancy prevention—reminder of measures to minimise teratogenic risk
NICE TA177: Alitretinoin for the treatment of severe chronic hand eczema
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Ichthammol with zinc oxide
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Formulary
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Bandage 7.5cm x 6m (Ichthopaste®)
Ointment zinc oxide 15% and ichthammol 1% in yellow soft paraffin (Special ointment No1) 
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Zinc Oxide
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Formulary
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Bandage 7.5cm x 6m (Viscopaste®)
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| 13.05.01 |
Topical preparations for eczema |
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| 13.05.02 |
Preparations for psoriasis |
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Dimethyl Fumarate (Skilarence®)
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Formulary
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Tablets 30mg, 120mg
The MHRA recommends that patients and their carers should be counselled on the risk of progressive multifocal leukoencephalopathy and advised to seek immediate medical attention if symptoms develop.
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NICE TA475: Dimethyl fumarate for treating moderate to severe plaque psoriasis
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Ixekizumab (Taltz®)
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Formulary


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Injection pre-filled pen 80mg/1ml Injection pre-filled syringe 80mg/1ml
Under expert supervision.
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NICE TA442: Ixekizumab for treating moderate to severe plaque psoriasis
NICE TA537: Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDs
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Spesolimab (Spevigo®)
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Formulary

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Solution for infusion 450mg/7.5ml
Under expert supervision.
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NICE TA1070: Spesolimab for treating generalised pustular psoriasis flares
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Methoxypsoralen
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Unlicensed
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Bath lotion 1.2%
Gel 0.005%
Tablets 10mg
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| 13.05.02 |
Topical preparations for psoriasis |
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Tacalcitol (Curatoderm®)
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Formulary
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Ointment 4micrograms/g
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Calcipotriol
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Formulary
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Ointment 50micrograms/g
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Calcipotriol with betamethasone
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Formulary
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Gel calcipotriol 0.005%, betamethasone dipropionate 0.05% Cutaneous foam calcipotriol 0.005%, betamethasone dipropionate 0.05% (Enstilar®)
Potent corticosteroid.
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Coal tar
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Formulary
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Lotion - Coal tar 5% (Exorex®)
Scalp Ointment - Coal tar 1%, salicylic acid 2%, precipitated sulfur 4% (Sebco®)
Ointment BP - Coal tar 2%, salicylic acid 2% - For scalp use only
Ointment - Coal tar, emulsifying ointment
Not all coal tar products are routinely stocked by pharmacy departments. If the product has to be obtained from a specials manufacturing unit there may be a delay of up to 4 weeks.
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Salicylic acid with zinc oxide (Lassars Paste)
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Formulary
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Paste zinc oxide 24%, salicylic acid 2%, starch 24%, white soft paraffin 50%
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Salicylic acid in emulsifying ointment
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Formulary
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Ointment 2%, 5%, 10%
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Dithranol in Lassar’s Paste
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Unlicensed
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10% (0.1%, 0.25%, 0.5%, 1%, 2%, 4%, 6%, 8% dilutions available from pharmacy) Not all dithranol products are routinely stocked by the pharmacy departments. If the product has to be obtained from a specials manufacturing unit there may be a delay for up to 4 weeks.
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| 13.05.02 |
Oral retinoids for psoriasis |
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Acitretin (Neotigason®)
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Formulary
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Capsules 10mg, 25mg
Prescribed by or under supervision of a consultant dermatologist.
Neuropsychiatric reactions have been reported in patients taking oral retinoids. The MHRA advises patients and carers to seek medical attention if changes in mood or behaviour occur.
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MHRA: Oral retinoids: pregnancy prevention—reminder of measures to minimise teratogenic risk
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| 13.05.03 |
Drugs affecting the immune response |
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Consultant dermatologist or specialist initiation only. To be prescribed in accordance with local and NICE guidance.
Medicines are commissioned by NHS England for paediatric indications where an adult NICE TA is in place. |
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Abrocitinib (Cibinqo ®)
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Formulary
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Tablets 50mg, 100mg, 200mg
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MHRA: Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
NICE TA814: Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitis
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Adalimumab
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Formulary

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S/C injection 40mg pre-filled syringe, pre-filled pen Tertiary centre only for hidradenitis suppurativa.
Commissioned in accordance with LSCMMG biologics pathways.
NHSE commissioned for some indications. Consult chapter links for more details.
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MHRA: Tumour necrosis factor alpha inhibitors
NICE TA199: Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis
NICE TA392: Adalimumab for treating moderate to severe hidradenitis suppurativa
NICE TA455: Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people
NIE TA146: Adalimumab for the treatment of adults with psoriasis
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Apremilast (Otezla®)
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Formulary

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Tablets 10mg, 20mg, 30mg
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MHRA: Apremilast (Otezla ▼): risk of suicidal thoughts and behaviour
NICE TA419: Apremilast for treating moderate to severe plaque psoriasis
NICE TA433: Apremilast for treating active psoriatic arthritis
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Azathioprine
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Formulary
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Tablets 25mg, 50mg
Some indications are unlicensed . Please consult product literature for licensing information.
Consultant dermatologist or specialist initiation only.
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LSCMMG: Azathioprine and Mercaptopurine shared care guideline
MHRA: Thiopurines and intrahepatic cholestasis of pregnancy
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Baricitinib
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Formulary
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Film-coated tablets 2mg, 4mg
Treatment of atopic dermatitis
Treatment of alopecia areata
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MHRA: Baricitinib (Olumiant▼): increased risk of diverticulitis, particularly in patients with risk factors
MHRA: Baricitinib (Olumiant▼): risk of venous thromboembolism
MHRA: Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
NICE TA681: Baricitinib for treating moderate to severe atopic dermatitis
NICE TA926: Baricitinib for treating severe alopecia areata
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Bimekizumab (Bimzelx ®)
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Formulary

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Solution for injection pre-filled pen 160mg/1ml, 320mg/2ml Solution for injection pre-filled syringe 160mg/1ml, 320mg/2ml
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NICE TA723: Bimekizumab for treating moderate to severe plaque psoriasis
NICE TA916: Bimekizumab for treating active psoriatic arthritis
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Brodalumab (Kyntheum®)
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Formulary
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Solution for injection pre-filled syringes 210mg/1.5ml
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NICE TA511: Brodalumab for treating moderate to severe plaque psoriasis
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Certolizumab pegol (Cimzia®)
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Formulary
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Solution for injection pre-filled pens 200mg/1ml Solution for injection pre-filled syringes 200mg/1ml Solution for injection in a dose-dispenser cartridge 200mg/1ml
Commissioned in accordance with LSCMMG biologics pathways. Consult chapter links for more details.
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MHRA: Tumour necrosis factor alpha inhibitors
NICE TA445: Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs
NICE TA574: Certolizumab pegol for treating moderate to severe plaque psoriasis
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Ciclosporin
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Formulary
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Capsules 10mg, 25mg, 50mg, 100mg Oral solution 100mg/ml
Consultant dermatologist or specilaist initiation only. Patients should be stabilised on a particular brand of oral ciclosporin because switching between formulations without close monitoring may lead to clinically important changes in blood-ciclosporin concentration.
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LSCMMG: Ciclosporin shared care guideline
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Deucravacitinib (Sotyktu®)
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Formulary
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Film coated tablets 6mg
It is not known whether deucravacitinib, an inhibitor of tyrosine kinase 2 (TYK2), is associated with the adverse reactions of Janus kinase (JAK) inhibition. Risks that have been identified as a class effect of JAK inhibitors include major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality.
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NICE TA907: Deucravacitinib for treating moderate to severe plaque psoriasis
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Dupilumab (Dupixent®)
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Formulary

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Solution for injection pre-filled pens 300mg/2ml, 200mg/1.14ml Solution for injection pre-filled syringes 300mg/2ml, 200mg/1.14ml
NICE TA955: Dupilumab for treating moderate to severe prurigo nodularis
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MHRA: Dupilumab (Dupixent▼): risk of ocular adverse reactions and need for prompt management
NICE TA534: Dupilumab for treating moderate to severe atopic dermatitis
NICE TA955: Dupilumab for treating moderate to severe prurigo nodularis
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Etanercept
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Formulary

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S/C injection 50mg pre-filled syringe, pre-filled pen
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MHRA: Tumour necrosis factor alpha inhibitors
NICE TA103: Etanercept and efalizumab for the treatment of adults with psoriasis
NICE TA199: Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis
NICE TA455: Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people
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Guselkumab (Tremfya®)
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Formulary

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Solution for injection in pre-filled pen 100mg/1ml
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NICE TA521: Guselkumab for treating moderate to severe plaque psoriasis
NICE TA815: Guselkumab for treating active psoriatic arthritis after inadequate response to DMARDs
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Infliximab
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Formulary
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Solution for injection pre-filled pen 120 mg/1ml
Adequate resuscitation facilities must be available when infliximab is used.
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MHRA: Tumour necrosis factor alpha inhibitors
NICE TA134: Infliximab for the treatment of adults with psoriasis
NICE TA199: Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis
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Lebrikizumab (Ebglyss®)
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Formulary
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Solution for injection pre-filled pens 250mg/2ml Solution for injection pre-filled syringes 250mg/2ml
The MHRA has reviewed the risk of dry eye and serious ocular side-effects associated with dupilumab, an inhibitor of interleukin-4 and interleukin-13 signalling. Lebrikizumab, which similarly inhibits interleukin-13, is also associated with ocular side-effects.
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MHRA: Dupilumab (Dupixent▼): risk of ocular adverse reactions and need for prompt management
NICE TA986: Lebrikizumab for treating moderate to severe atopic dermatitis in people 12 years and over
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Methotrexate
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Formulary
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Tablets 2.5mg Prefilled syringes and pens (various strengths)
Methotrexate should be prescribed once weekly as a single dose on the same day each week. If oral methotrexate is prescribed only use the 2.5 mg strength. See hospital policy for prescribing and supply of oral methotrexate.
Methotrexate subcutaneous injection may be supplied through a homecare arrangement.
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LSCMMG: Methotrexate shared care guideline
MHRA: Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing
MHRA: Methotrexate: advise patients to take precautions in the sun to avoid photosensitivity reactions
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Nemolizumab (Nemluvio®)
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Formulary

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30 mg powder and solvent for solution for injection in pre-filled pen
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NICE TA1077: Nemolizumab for treating moderate to severe atopic dermatitis in people 12 years and over
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Omalizumab (Xolair®)
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Formulary
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Solution for injection pre-filled pens 75mg/0.5ml, 150mg/1ml, 300mg/2ml Solution for injection pre-filled syringes 75mg/0.5ml, 150mg/1ml, 300mg/2ml
Unlicensed use of omalizumab for severe chronic inducible urticarias.
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LSCMMG: Commissioning statement Unlicensed use of omalizumab for severe chronic inducible urticarias
MHRA: Omalizumab: potential risk of arterial thrombotic events
NICE TA339: Omalizumab for previously treated chronic spontaneous urticaria
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Pimecrolimus (Elidel®)
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Formulary
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Cream 1%
Consultant dermatologist or specilaist initiation only.
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NICE TA82: Tacrolimus and pimecrolimus for atopic eczema
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Risankizumab (Skyrizi®)
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Formulary
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Solution for injection pre-filled syringes 150mg/mL Solution for injection pre-filled pen 150mg/mL Solution for injection cartridges 180mg/1.2ml, 360mg/2.4ml
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NICE TA596: Risankizumab for treating moderate to severe plaque psoriasis
NICE TA803: Risankizumab for treating active psoriatic arthritis after inadequate response to DMARDs
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Ritlecitinib (Litfulo®)
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Formulary
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Capsules 50mg
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BAD: Professional guidance supplementary to NICE TA958
MHRA: Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
NICE TA958: Ritlecitinib for treating severe alopecia areata in people 12 years and over
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Secukinumab (Cosentyx®)
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Formulary

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Solution for injection pre-filled pens 150mg/1ml, 300mg/2ml Solution for injection pre-filled syringes 75mg/0.5ml, 150mg/1ml
NHSE commissioned for some indications.
Approved by LSCMMG for palmoplantar psoriasis 
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LSCMMG: Secukinumab (Cosentyx▼) NMR
NICE TA350: Secukinumab for treating moderate to severe plaque psoriasis
NICE TA445: Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs
NICE TA734: Secukinumab for treating moderate to severe plaque psoriasis in children and young people
NICE TA935: Secukinumab for treating moderate to severe hidradenitis suppurativa
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Tacrolimus
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Formulary
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Ointment 0.03%, 0.1%
Psoriasis. Consultant dermatologist or specilaist initiation only.
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MHRA: Tacrolimus ointment (Protopic): possible risk of malignancies including lymphomas and skin cancers
NICE TA82: Tacrolimus and pimecrolimus for atopic eczema
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Tildrakizumab (Ilumetri®)
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Formulary
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Solution for injection pre-filled syringes 100mg/1ml
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NICE TA575: Tildrakizumab for treating moderate to severe plaque psoriasis
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Tralokinumab (Adtralza ®)
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Formulary
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Solution for injection pre-filled syringes 150mg/1ml Solution for injection pre-filled pens 300mg/2ml
The MHRA has reviewed the risk of dry eye and serious ocular side-effects associated with dupilumab, an inhibitor of interleukin-4 and interleukin-13 signalling. Tralokinumab, which similarly inhibits interleukin-13, is also associated with ocular side-effects.
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MHRA: Dupilumab (Dupixent▼): risk of ocular adverse reactions and need for prompt management
NICE TA814: Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitis
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Upadacitinib (Rinvoq ®)
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Formulary

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Prolonged release tablets 15mg, 30mg, 45mg
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MHRA: Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
NICE TA814: Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitis
NICE768: Upadacitinib for treating active psoriatic arthritis after inadequate response to DMARDs
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Ustekinumab
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Formulary

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Solution for injection pre-filled syringes 45mg/0.5ml, 90mg/1ml
Consultant dermatologist or specialist initiation only.
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MHRA: Ustekinumab (Stelara): risk of exfoliative dermatitis
NICE TA180: Ustekinumab for the treatment of adults with moderate to severe psoriasis
NICE TA340: Ustekinumab for treating active psoriatic arthritis
NICE TA455: Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people
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| 13.06 |
Acne and rosacea |
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Brimonidine tartrate (Mirvaso® )
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Formulary
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Gel 3mg/g
Restricted to use in patients with moderate to severe, persistent facial erythema of rosacea.
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LSCMMG: Brimonidine Tartrate (Mirvaso) 3mg/g Gel NMR
MHRA: Brimonidine gel (Mirvaso): risk of exacerbation of rosacea
MHRA: Brimonidine gel (Mirvaso): risk of systemic cardiovascular effects; not to be applied to damaged skin
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Ivermectin
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Formulary
|
Cream 10mg/g
Topical treatment of inflammatory lesions of rosacea (papulopustular) in adults.
Appropriate for initiation and on-going prescribing in both primary and secondary care. To be used as an alternative treatment when metronidazole and azelaic acid topical preparations are not effective, contraindicated or not tolerated by the patient. Ivermectin cream may be tried for a 3 month period, at which point it can be stopped if not effective or continued if effective.
For indications relating to oral ivermectin see subsection 05.05 Anthelmintics.
|
LSCMMG: Ivermectin cream 10mg/g (Soolantra®) NMR
|
| 13.06.01 |
Topical preparations for acne |
|
|
| 13.06.01 |
Benzoyl peroxide and azelaic acid |
|
|
Azelaic Acid
|
Formulary
|
Gel 15% (Finacae®) Cream 20% (Skinoren®)
|
|
|
Benzoyl Peroxide (Acnecide®)
|
Formulary
|
Gel 5%
If sun exposure is unavoidable, an appropriate sunscreen or protective clothing should be used.
|
|
|
Benzoyl peroxide with clindamycin
|
Formulary
|
Gel benzoyl peroxide 5%, clindamycin 1%
If sun exposure is unavoidable, an appropriate sunscreen or protective clothing should be used.
|
|
|
| 13.06.01 |
Topical antibacterials for acne |
|
|
Erythromycin with zinc acetate
|
Formulary
|
Lotion erythromycin 40mg/ml, zinc acetate 12mg/ml
|
|
|
Clindamycin
|
Formulary
|
Lotion 1% Gel 1% (Zindaclin®)
|
|
|
| 13.06.01 |
Topical retinoids and related preparations for acne |
|
|
|
If sun exposure is unavoidable, an appropriate sunscreen or protective clothing should be used. |
|
Adapalene (Differin®)
|
Formulary
|
Cream 0.1% Gel 0.1%
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
|
|
|
Adapalene with benzoyl peroxide
|
Formulary
|
Gel adapalene 0.1%, benzoyl peroxide 2.5%
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
|
|
|
Tretinoin with clindamycin (Treclin®)
|
Formulary
|
Gel clindamycin 1%, tretinoin 0.025%
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
|
|
|
Trifarotene (Aklief®)
|
Formulary
|
Cream 50micrograms/g
Acne vulgaris of the face and/or the trunk in patients from 12 years of age and older, when many comedones, papules and pustules are present.
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
|
LSCMMG: Trifarotene (Aklief®) 50 microgram/g cream NMR
|
| 13.06.01 |
Other topical preparations for acne |
|
|
| 13.06.02 |
Oral preparations for acne |
|
|
| 13.06.02 |
Oral antibiotics for acne |
|
|
Doxycycline
|
Formulary
|
Capsules 50mg, 100mg Dispersible tablets 100mg
|
|
|
Erythromycin
|
Formulary
|
Tablets e/c 250mg Suspension 125mg/5mL, 250mg/5mL
|
MHRA: Erythromycin: caution required due to cardiac risks (QT interval prolongation); drug interaction with rivaroxaban
MHRA: Erythromycin: update on known risk of infantile hypertrophic pyloric stenosis
|
Lymecycline
|
Formulary
|
Capsules 408mg
|
|
|
Oxytetracycline
|
Formulary
|
Tablets 250mg
|
|
|
| 13.06.02 |
Hormone treatment for acne |
|
|
Co-Cyprindiol
|
Formulary
|
Tablets cyproterone 2mg / ethinylestradiol 35 micrograms
|
MHRA: Cyproterone acetate with ethinylestradiol (co-cyprindiol): balance of benefits and risks remains positive
MHRA: Cyproterone acetate: new advice to minimise risk of meningioma
|
| 13.06.02 |
Oral retinoid for acne |
|
|
Isotretinoin
|
Formulary
|
Capsules 5mg, 10mg, 20mg Consultant dermatologist or specialist only.
As a RED drug, isotretinoin should be supplied by secondary care. Local exceptions to this are for patients under the care of the consultant-led integrated community dermatology service, OMNES.
Community pharmacies can dispense FP10s for isotretinoin from OMNES where it is clear that the prescription has been issued within the context of a Pregnancy Prevention Programme. Do not dispense 7 days beyond issue date of FP10. Please refer the pharmacy checklist and Isotretinoin (Roaccutane▼): introduction of new safety measures, including additional oversight of the initiation of treatment for patients under 18 years of age
Contra-indicated in patients with hypersensitivity to peanuts or soya (capsule filling contains soya-bean oil).
Neuropsychiatric reactions have been reported in patients taking oral retinoids. The MHRA advises patients and carers to seek medical attention if changes in mood or behaviour occur.
Patients should avoid excessive exposure to UV light (including sunlight, solariums)—sunscreen with a high protection factor should be applied.
|
MHRA: Isotretinoin (Roaccutane▼): introduction of new safety measures, including additional oversight of the initiation of treatment for patients under 18 years of age
MHRA: Isotretinoin: risk of serious skin reactions
MHRA: Oral retinoid medicines▼: revised and simplified pregnancy prevention educational materials for healthcare professionals and women
MHRA: Oral retinoids: pregnancy prevention—reminder of measures to minimise teratogenic risk
|
|
|
| 13.06.03 |
Topical preparations for rosacea |
|
|
| 13.07 |
Preparations for warts and calluses |
|
|
Salicylic acid with lactic acid
|
Formulary
|
Paint 10mL
|
|
|
Salicylic Acid
|
Formulary
|
Solution 26%
|
|
|
Silver Nitrate (Avoca®)
|
Formulary
|
Caustic applicator 75%
for Warts
for over-granulating wounds
|
|
|
| 13.07 |
Anogenital warts |
|
|
Imiquimod (Aldara®)
|
Formulary
|
Cream 5%
External genital warts.
|
|
|
Podophyllotoxin (Warticon®)
|
Formulary
|
Cream 0.15% Solution 0.5%
|
|
|
| 13.08 |
Sunscreens and camouflagers |
|
|
| 13.08.01 |
Sunscreen preparations |
|
|
|
Some sunscreen products have ACBS approval. They may be prescribed for skin protection against ultraviolet radiation and/or visible light in abnormal cutaneous photosensitivity causing severe cutaneous reactions in genetic disorders (including xeroderma pigmentosum and porphyrias), severe photodermatoses (both idiopathic and acquired) and in those with increased risk of ultraviolet radiation causing adverse effects due to chronic disease (such as haematological malignancies), medical therapies and/or procedures. |
|
Anthelios®
|
Formulary
|
Sunscreen Lotion SPF 50+
For ACBS conditions only, otherwise self care.
|
|
|
Uvistat®
|
Formulary
|
Lipscreen SPF 50, Suncream SPF 30, and Suncream SPF 50.
For ACBS conditions only, otherwise self care.
|
|
|
| 13.08.01 |
Photodamage |
|
|
Diclofenac
|
Formulary
|
Gel 3%
|
|
|
Tirbanibulin (Klisyri ®)
|
Formulary
|
Ointment 10 mg/g
|
|
|
Fluorouracil (Efudix®)
|
Formulary
|
Cream 5%
Treatment of superficial pre-malignant skin lesions (e.g. actinic keratosis) - Prescribers should refer patients with skin lesions suggestive of skin cancers using the principles of the NICE suspected cancer guideline. Patients must be counselled in full on the correct use of fluorouracil 5% Cream, its risks and side effects.
Treatment of small superficial basal-cell carcinomas in adults - Only to be prescribed by skin cancer specialists or a suitably qualified GP with specialist interest (GPwSI) with demonstrable clinical skills and competencies, training and experience.
|
LSCMMG: Fluorouracil 5% Cream NMR
LSCMMG: Imiquimod cream (Aldara) and fluorouracil cream (Efudix) NMR
|
Fluorouracil (Tolak®)
|
Formulary
|
Cream 4%
For treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis (Olsen grade I and II) of the face, ears, and/or scalp in adults.
Prescribers should refer patients with skin lesions suggestive of skin cancers using the principles of the NICE suspected cancer guideline. Patients must be counselled in full on the correct use of fluorouracil 4% Cream, its risks and side effects.
|
|
|
Aminolevulinic acid (Ameluz®)
|
Formulary
|
Gel 78mg/g
|
|
|
Imiquimod
|
Formulary
|
Cream 5% (Aldara®) Treatment of actinic keratosis
Cream 5% (Aldara®) Treatment of small superficial basal-cell carcinomas in adults - Only to be prescribed by skin cancer specialists or a suitably qualified GP with specialist interest (GPwSI) with demonstrable clinical skills and competencies, training and experience.
Cream 3.75% (Zyclara®) Treatment of Actinic Keratosis ial basal cell carcinoma in adults
|
LSCMMG: Imiquimod cream (Aldara) and fluorouracil cream (Efudix) NMR
|
Methyl-5-Aminolevulinate (Metvix®)
|
Formulary
|
Cream 160 mg/g
|
|
|
Fluorouracil with salicylic acid (Actikerall®)
|
Formulary
|
Solution fluorouracil 0.5%, salicylic acid 10%
|
|
|
| 13.08.02 |
Camouflagers |
|
|
Ruxolitinib cream
|
Formulary
|
For treating non-segmental vitiligo in people 12 years and over
|
NICE TA1088: Ruxolitinib cream for treating non-segmental vitiligo in people 12 years and over
|
| 13.09 |
Shampoos and other preparations for scalp and hair conditions |
|
|
Coal Tar
|
Formulary
|
Shampoo
Consider OTC/Self care.
|
|
|
Coal tar with coconut oil and salicylic acid (Capasal®)
|
Formulary
|
Shampoo coal tar distilled 10mg per 1gram, Coconut oil 10mg per 1gram, Salicylic acid 5mg per 1gram
Consider OTC/Self care.
|
|
|
Ketoconazole
|
Formulary
|
Shampoo 2%
Consider OTC/Self care.
|
|
|
| 13.09 |
Hirsutism |
|
|
Eflornithine (Vaniqa®)
|
Formulary
|
|
LSCMMG: Eflornithine (Vaniqa®) NMR
|
| 13.09 |
Androgenetic alopecia |
|
|
| 13.10 |
Anti-infective skin preparations |
|
|
| 13.10.01 |
Antibacterial preparations |
|
|
| 13.10.01.01 |
Antibacterial preparations only used topically |
|
|
Mupirocin (Bactroban®)
|
Formulary
|
Cream 2%
|
|
|
Silver sulfadiazine (Flamazine®)
|
Formulary
|
Cream 1%
|
|
|
| 13.10.01.02 |
Antibacterial preparations also used systemically |
|
|
Fusidic acid (Sodium fusidate)
|
Formulary
|
Cream 2% Ointment 2%
To avoid the development of resistance, fusidic acid should not be used for longer than 10 days and local microbiology advice should be sought before using it in hospital.
|
|
|
Metronidazole
|
Formulary
|
Gel 0.75%
Cream 0.75%
|
|
|
| 13.10.02 |
Antifungal preparations |
|
|
Clotrimazole
|
Formulary
|
Cream 1%
Consider OTC/Self care.
|
|
|
Miconazole
|
Formulary
|
Cream 2%
Consider OTC/Self care.
|
MHRA: Topical miconazole, including oral gel: reminder of potential for serious interactions with warfarin
|
Terbinafine
|
Formulary
|
Cream 1%
Consider OTC/Self care.
|
|
|
| 13.10.03 |
Antiviral preparations |
|
|
Aciclovir
|
Formulary
|
Cream 5%
Consider OTC/Self care.
|
|
|
| 13.10.04 |
Parasiticidal preparations |
|
|
| 13.10.04 |
Scabies |
|
|
| 13.10.04 |
Head lice |
|
|
| 13.10.04 |
Crab lice |
|
|
| 13.10.04 |
Benzyl benzonate |
|
|
| 13.10.04 |
Carbaryl |
|
|
| 13.10.04 |
Dimeticone |
|
|
Dimeticone (Hedrin®)
|
Formulary
|
Lotion 4%
Consider OTC/Self care.
|
MHRA: Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarett
|
| 13.10.04 |
Malathion |
|
|
Malathion (Derbac-M®)
|
Formulary
|
Liquid 0.5%
Consider OTC/Self care.
|
MHRA: Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarett
|
| 13.10.04 |
Permethrin |
|
|
Permethrin
|
Formulary
|
Cream 5%
Consider OTC/Self care.
|
MHRA: Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes
|
| 13.10.04 |
Phenothrin |
|
|
| 13.10.05 |
Preparations for minor cuts and abrasions |
|
|
| 13.10.05 |
Collodion |
|
|
| 13.10.05 |
Skin tissue adhesive |
|
|
| 13.11 |
Skin cleansers, antiseptics, and desloughing agents |
|
|
Octenisan®
|
Formulary
|
Antimicrobial wash
|
|
|
| 13.11.01 |
Alcohols and saline |
|
|
| 13.11.02 |
Chlorhexidine salts |
|
|
Chlorhexidine
|
Formulary
|
Cleansing solution 4% (Hibiwash®)
Cream 1% (Hibitane Obstetric®)
|
MHRA: All medical devices and medicinal products containing chlorhexidine - Risk of anaphylactic reaction due to chlorhexidine allergy
MHRA: Chlorhexidine solutions: reminder of the risk of chemical burns in premature infants
|
| 13.11.03 |
Cationic surfactants and soaps |
|
|
| 13.11.04 |
Iodine and Chlorine |
|
|
| 13.11.05 |
Phenolics |
|
|
| 13.11.06 |
Oxidisers, and dyes |
|
|
Hydrogen Peroxide (Crystacide®)
|
Formulary
|
Cream 1%
|
|
|
Potassium Permanganate (Permitabs®)
|
Formulary
|
**RAG position and advisory notes currently under review. Follow local protocols. Contact your local medicines management team if futher advice is required.**
Solution tablets 400mg
Primary Care : Potassium permanganate should always be prescribed for a named patient by a primary care prescriber, experienced in the treatment of dermatological conditions and use of potassium permanganate.
Secondary Care:- Potassium permanganate concentrate should always be prescribed for a named patient by a specialist in dermatology, a clinician working under the guidance of a dermatologist, or specialist tissue viability staff only.
Note: A risk assessment must be completed if potassium permanganate is to be used in a patient's home.
Potassium permanganate is for external use only. Oral ingestion can cause fatality due to local inflammatory reactions that block the airways or cause perforations of the gastrointestinal tract, or through toxicity and organ failure. Potassium permanganate is subject to the requirements of Control of Substances Hazardous to Health including: separate storage, additional hazard labelling, and issue only to staff and patients who have been educated to understand its safe use. Accidental ingestion should be treated as a medical emergency.
|
BAD and NHS England & NHS Improvement guidance on the safe use of potassium permanganate soaks
BAD: Potassium permanganate solution soaks
NHS Central alerting system
|
| 13.11.07 |
Desloughing agents |
|
|
Sterile Larvae (Maggots)
|
Formulary
|
Available to order for named patients.
|
|
|
| 13.11.07 |
Desloughing agents |
|
|
| 13.11.07 |
Growth factor |
|
|
| 13.12 |
Antiperspirants |
|
|
Botulinum toxin type A
|
Formulary
|
Powder for solution for injection Preparations are not interchangeable.
For treatment of primary idiopathic hyperhidrosis and secondary hyperhidrosis.
- as an option for the management of severe primary idiopathic hyperhidrosis of the axillae, which does not respond to self-care strategies and topical treatment, and where the cause is NOT due to social anxiety.
- as an option for the management of severe secondary hyperhidrosis of the axillae, which does not respond to self-care strategies and topical treatment, where the cause is NOT due to social anxiety and where the primary condition has been optimally managed as far as reasonable to alleviate the hyperhidrosis.
In order to reduce the potential for antibody formation which reduces the effectiveness of treatment, inject the lowest effective dose at the longest clinically indicated interval.
|
LSCMMG: Botulinum Toxin Type A for primary idiopathic hyperhidrosis and secondary hyperhidrosis NMR
LSCMMG: Stepwise approach to hyperhidrosis management
|
| 13.13 |
Topical circulatory preparations |
|
|
| 13.14 |
dermatology specials |
|
|
| .... |
Key |
 |
Restricted Drug |
 |
Unlicensed |
|
|
Link to adult BNF
|
|
|
Link to children's BNF
|
|
|
Link to SPCs
|
|
Scottish Medicines Consortium |
|
Cytotoxic Drug |
|
Controlled Drug |
|
|
High Cost Medicine
|
|
Cancer Drugs Fund
|
|
Homecare |
|
ICB commissioned |
|
NHS England commissioned |
|
Blueteq form needed |
|
Low carbon footprint |
|
Medium carbon footprint |
|
High carbon footprint |
|
| Status |
Description |

|
Green:
Appropriate for initiation and ongoing prescribing in both primary and secondary care.
Generally, little or no routine drug monitoring is required. |

|
Green (Restricted):
Appropriate for initiation and ongoing prescribing in both primary and secondary care provided:
Additional criteria specific to the medicine or device are met, or
The medicine or device is used following the failure of other therapies as defined by the relevant LSCMMG pathway.
Generally, little or no routine drug monitoring is required.
|

|
Red medicines:
Medicine is supplied by the hospital for the duration of the treatment course.
Primary care initiation or continuation of treatment is not recommended unless exceptional circumstances such as specialist GP.
Red medicines are those where primary care prescribing is not recommended. These treatments should be initiated by specialists only and prescribing retained within secondary care. They require specialist knowledge, intensive monitoring, specific dose adjustments or further evaluation in use. If however, a primary care prescriber has particular specialist knowledge or experience of prescribing a particular drug for a particular patient it would not always be appropriate for them to expect to transfer that prescribing responsibility back to secondary care. There should be a specific reason and a specific risk agreement, protocol and service set up to support this.
Primary care prescribers may prescribe RED medicines in exceptional circumstances to patients to ensure continuity of supply while arrangements are made to obtain ongoing supplies from secondary care. |

|
Amber level 0:
Suitable for prescribing in primary care following recommendation or initiation by a specialist.
Little or no specific monitoring required.
Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care.
Brief prescribing document or information sheet may be required.
Primary care prescribers must be familiar with the drug to take on prescribing responsibility or must get the required information.
When recommending or handing over care, specialists should ask primary care prescribers to take over prescribing responsibility, and should give enough information about the indication, dose, monitoring requirements, use outside product licence and any necessary dose adjustments to allow them to confidently prescribe. |

|
Amber level 1 (with shared care):
Suitable for prescribing in primary care following recommendation or initiation by a specialist.
Minimal monitoring required.
Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care.
Full prior agreement about patient’s on-going care must be reached under the shared care agreement.
Primary care prescribers are advised not to take on prescribing of these medicines unless they have been adequately informed by letter of their responsibilities with regards monitoring, side effects and interactions and are happy to take on the prescribing responsibility. A copy of locally approved shared care guidelines should accompany this letter which outlines these responsibilities. Primary care prescribers should then tell secondary care of their intentions as soon as possible by letter so that arrangements can be made for the transfer of care. |

|
Amber level 2 (with shared care and enhanced service):
Initiated by specialist and transferred to primary care following a successful initiation period.
Significant monitoring required on an on-going basis.
Full prior agreement about patient’s on-going care must be reached under the shared care agreement.
Suitable for enhanced service.
These medicines are considered suitable for GP prescribing following specialist initiation of therapy, as per shared care document which will be sent out with the request to prescribe, with on-going communication between the primary care prescriber and specialist. Amber Level 2 medicines require significant monitoring for which an enhanced service may be suitable. (Subject to local commissioning agreements). |

|
Do not prescribe: NOT recommended for use by the NHS in Lancashire and South Cumbria.
Includes medicines that NICE has not recommended for use and terminated technology appraisals, unless there is a local need. |

|
Grey medicines:
Medicines which have not yet been reviewed or are under the review process.
GPs and specialists are recommended not to prescribe these drugs.
This category includes drugs where funding has not yet been agreed.
|

|
Refer to local guidance. |
|
|
|