| Formulary Chapter 13: Skin - Full Chapter
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| Chapter Links... |
LSCMMG: Guidelines for the Management of Psoriasis in Primary Care |
LSCMMG: Position Statement: Prescribing of Medical Camouflaging Products |
LSCMMG: Psoriasis in adults: LSCMMG Biologic and High Cost Drug Commissioning Pathway |
NICE CG153: Psoriasis: assessment and management |
NICE CG57: Atopic eczema in under 12s: diagnosis and management |
NICE NG12: Suspected cancer: recognition and referral |
NICE NG14: Melanoma: assessment and management |
NICE NG198: Acne vulgaris: management |
| Details... |
| 13.06 |
Acne and rosacea |
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Brimonidine tartrate (Mirvaso® )
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Formulary
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Gel 3mg/g
Restricted to use in patients with moderate to severe, persistent facial erythema of rosacea.
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LSCMMG: Brimonidine Tartrate (Mirvaso) 3mg/g Gel NMR
MHRA: Brimonidine gel (Mirvaso): risk of exacerbation of rosacea
MHRA: Brimonidine gel (Mirvaso): risk of systemic cardiovascular effects; not to be applied to damaged skin
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Ivermectin
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Formulary
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Cream 10mg/g
Topical treatment of inflammatory lesions of rosacea (papulopustular) in adults.
Appropriate for initiation and on-going prescribing in both primary and secondary care. To be used as an alternative treatment when metronidazole and azelaic acid topical preparations are not effective, contraindicated or not tolerated by the patient. Ivermectin cream may be tried for a 3 month period, at which point it can be stopped if not effective or continued if effective.
For indications relating to oral ivermectin see subsection 05.05 Anthelmintics.
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LSCMMG: Ivermectin cream 10mg/g (Soolantra®) NMR
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| 13.06.01 |
Topical preparations for acne |
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| 13.06.01 |
Benzoyl peroxide and azelaic acid |
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Azelaic Acid
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Formulary
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Gel 15% (Finacae®) Cream 20% (Skinoren®)
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Benzoyl Peroxide (Acnecide®)
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Formulary
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Gel 5%
If sun exposure is unavoidable, an appropriate sunscreen or protective clothing should be used.
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Benzoyl peroxide with clindamycin
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Formulary
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Gel benzoyl peroxide 5%, clindamycin 1%
If sun exposure is unavoidable, an appropriate sunscreen or protective clothing should be used.
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| 13.06.01 |
Topical antibacterials for acne |
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Erythromycin with zinc acetate
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Formulary
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Lotion erythromycin 40mg/ml, zinc acetate 12mg/ml
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Clindamycin
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Formulary
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Lotion 1% Gel 1% (Zindaclin®)
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| 13.06.01 |
Topical retinoids and related preparations for acne |
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If sun exposure is unavoidable, an appropriate sunscreen or protective clothing should be used. |
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Adapalene (Differin®)
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Formulary
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Cream 0.1% Gel 0.1%
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
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Adapalene with benzoyl peroxide
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Formulary
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Gel adapalene 0.1%, benzoyl peroxide 2.5%
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
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Tretinoin with clindamycin (Treclin®)
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Formulary
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Gel clindamycin 1%, tretinoin 0.025%
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
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Trifarotene (Aklief®)
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Formulary
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Cream 50micrograms/g
Acne vulgaris of the face and/or the trunk in patients from 12 years of age and older, when many comedones, papules and pustules are present.
The MHRA advises females of childbearing potential should use effective contraception.
Contraindicated during pregnancy.
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LSCMMG: Trifarotene (Aklief®) 50 microgram/g cream NMR
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| 13.06.01 |
Other topical preparations for acne |
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| 13.06.02 |
Oral preparations for acne |
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| 13.06.02 |
Oral antibiotics for acne |
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Doxycycline
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Formulary
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Capsules 50mg, 100mg Dispersible tablets 100mg
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Erythromycin
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Formulary
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Tablets e/c 250mg Suspension 125mg/5mL, 250mg/5mL
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MHRA: Erythromycin: caution required due to cardiac risks (QT interval prolongation); drug interaction with rivaroxaban
MHRA: Erythromycin: update on known risk of infantile hypertrophic pyloric stenosis
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Lymecycline
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Formulary
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Capsules 408mg
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Oxytetracycline
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Formulary
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Tablets 250mg
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| 13.06.02 |
Hormone treatment for acne |
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Co-Cyprindiol
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Formulary
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Tablets cyproterone 2mg / ethinylestradiol 35 micrograms
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MHRA: Cyproterone acetate with ethinylestradiol (co-cyprindiol): balance of benefits and risks remains positive
MHRA: Cyproterone acetate: new advice to minimise risk of meningioma
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| 13.06.02 |
Oral retinoid for acne |
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Isotretinoin
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Formulary
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Capsules 5mg, 10mg, 20mg Consultant dermatologist or specialist only.
As a RED drug, isotretinoin should be supplied by secondary care. Local exceptions to this are for patients under the care of the consultant-led integrated community dermatology service, OMNES.
Community pharmacies can dispense FP10s for isotretinoin from OMNES where it is clear that the prescription has been issued within the context of a Pregnancy Prevention Programme. Do not dispense 7 days beyond issue date of FP10. Please refer the pharmacy checklist and Isotretinoin (Roaccutane▼): introduction of new safety measures, including additional oversight of the initiation of treatment for patients under 18 years of age
Contra-indicated in patients with hypersensitivity to peanuts or soya (capsule filling contains soya-bean oil).
Neuropsychiatric reactions have been reported in patients taking oral retinoids. The MHRA advises patients and carers to seek medical attention if changes in mood or behaviour occur.
Patients should avoid excessive exposure to UV light (including sunlight, solariums)—sunscreen with a high protection factor should be applied.
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MHRA: Isotretinoin – updates to prescribing guidance and survey of services
MHRA: Isotretinoin (Roaccutane▼): introduction of new safety measures, including additional oversight of the initiation of treatment for patients under 18 years of age
MHRA: Isotretinoin: risk of serious skin reactions
MHRA: Oral retinoid medicines▼: revised and simplified pregnancy prevention educational materials for healthcare professionals and women
MHRA: Oral retinoids: pregnancy prevention—reminder of measures to minimise teratogenic risk
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| 13.06.03 |
Topical preparations for rosacea |
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Key |
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Restricted Drug |
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Unlicensed |
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
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Scottish Medicines Consortium |
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Cytotoxic Drug |
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Controlled Drug |
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High Cost Medicine
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Cancer Drugs Fund
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Homecare |
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ICB commissioned |
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NHS England commissioned |
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Blueteq form needed |
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Low carbon footprint |
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Medium carbon footprint |
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High carbon footprint |
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| Status |
Description |

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Green:
Appropriate for initiation and ongoing prescribing in both primary and secondary care.
Generally, little or no routine drug monitoring is required. |

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Green (Restricted):
Appropriate for initiation and ongoing prescribing in both primary and secondary care provided:
Additional criteria specific to the medicine or device are met, or
The medicine or device is used following the failure of other therapies as defined by the relevant LSCMMG pathway.
Generally, little or no routine drug monitoring is required.
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Red medicines:
Medicine is supplied by the hospital for the duration of the treatment course.
Primary care initiation or continuation of treatment is not recommended unless exceptional circumstances such as specialist GP.
Red medicines are those where primary care prescribing is not recommended. These treatments should be initiated by specialists only and prescribing retained within secondary care. They require specialist knowledge, intensive monitoring, specific dose adjustments or further evaluation in use. If however, a primary care prescriber has particular specialist knowledge or experience of prescribing a particular drug for a particular patient it would not always be appropriate for them to expect to transfer that prescribing responsibility back to secondary care. There should be a specific reason and a specific risk agreement, protocol and service set up to support this.
Primary care prescribers may prescribe RED medicines in exceptional circumstances to patients to ensure continuity of supply while arrangements are made to obtain ongoing supplies from secondary care. |

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Amber level 0:
Suitable for prescribing in primary care following recommendation or initiation by a specialist.
Little or no specific monitoring required.
Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care.
Brief prescribing document or information sheet may be required.
Primary care prescribers must be familiar with the drug to take on prescribing responsibility or must get the required information.
When recommending or handing over care, specialists should ask primary care prescribers to take over prescribing responsibility, and should give enough information about the indication, dose, monitoring requirements, use outside product licence and any necessary dose adjustments to allow them to confidently prescribe. |

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Amber level 1 (with shared care):
Suitable for prescribing in primary care following recommendation or initiation by a specialist.
Minimal monitoring required.
Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care.
Full prior agreement about patient’s on-going care must be reached under the shared care agreement.
Primary care prescribers are advised not to take on prescribing of these medicines unless they have been adequately informed by letter of their responsibilities with regards monitoring, side effects and interactions and are happy to take on the prescribing responsibility. A copy of locally approved shared care guidelines should accompany this letter which outlines these responsibilities. Primary care prescribers should then tell secondary care of their intentions as soon as possible by letter so that arrangements can be made for the transfer of care. |

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Amber level 2 (with shared care and enhanced service):
Initiated by specialist and transferred to primary care following a successful initiation period.
Significant monitoring required on an on-going basis.
Full prior agreement about patient’s on-going care must be reached under the shared care agreement.
Suitable for enhanced service.
These medicines are considered suitable for GP prescribing following specialist initiation of therapy, as per shared care document which will be sent out with the request to prescribe, with on-going communication between the primary care prescriber and specialist. Amber Level 2 medicines require significant monitoring for which an enhanced service may be suitable. (Subject to local commissioning agreements). |

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Do not prescribe: NOT recommended for use by the NHS in Lancashire and South Cumbria.
Includes medicines that NICE has not recommended for use and terminated technology appraisals, unless there is a local need. |

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Grey medicines:
Medicines which have not yet been reviewed or are under the review process.
GPs and specialists are recommended not to prescribe these drugs.
This category includes drugs where funding has not yet been agreed.
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Refer to local guidance. |
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