Lancashire and South Cumbria
Formulary
Formulary
4 Central nervous system
04-01-01 Non-benzodiazepine hypnotics and sedatives
Avoid prescribing hypnotics. Hypnotics licensed for short term use only - If needed, use for 1-3 days only. Do not supply on discharge from hospital.
On specialist advice only, some patients with long term psychiatric problems may require long term use.
| Zopiclone |
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Formulary
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Tablets 3.75mg, 7.5mg If commenced in hospital, not to be continued at discharge. |
 NICE TA77: Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia |
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| Daridorexant |
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Formulary
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Tablets 25mg, 50mg Treatment of long-term insomnia. Restrictions as per NICE TA. |
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NICE TA922: Daridorexant for treating long-term insomnia |
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| Melatonin |
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Formulary
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Sleep problems in children with learning disabilities
Sleep problems in children with ADHD
Sleep problems in children and adolescents with Autism Spectrum Disorder (ASD) and / or Smith-Magenis syndrome
Sleep disturbances in Cerebral Palsy in under 25s
Sleep problems in children with complex neurodevelopmental disorders that the specialist considers eligible
Initiation of melatonin must be by a specialist in the indication being prescribed for and have a clear plan for review.
Prescribing and review of melatonin in children must follow the principles outlined in the Melatonin Pathway (Children).
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 LSCMMG: Melatonin Pathway (Children) |
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| Melatonin |
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Formulary
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For the Treatment of Rapid Eye Movement (REM) Sleep Behaviour Disorder (RBD) in Parkinson’s Disease and Lewy Body Dementia (when clonazepam is not considered to be appropriate)
Sleep problems in adults with learning disabilities
Sleep problems in adults with ADHD
Adults with sleep disorders who are totally blind
Sleep disturbances in Cerebral Palsy in under 25s
Sleep problems in adults with complex neurodevelopmental disorders that the specialist considers eligible
Young people on established melatonin therapy who are transitioning into adult services
Initiation of melatonin must be by a specialist in the indication being prescribed for and have a clear plan for review.
Prescribing and review of melatonin in adults must follow the principles outlined in LSCMMG guidance 'Insomnia in Adults'. |
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LSCMMG: Insomnia in Adults LSCMMG: Melatonin prolonged release tablets (Circadin®) NMR |
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| Zolpidem |
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Formulary
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Tablets 5mg, 10mg |
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MHRA: Zolpidem: risk of drowsiness and reduced driving ability NICE TA77: Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia |
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Links
- LSCMMG: Insomnia in Adults
- LSCMMG: Insomnia in Adults
- LSCMMG: Melatonin Pathway (Children)
- LSCMMG: Melatonin prolonged release tablets (Circadin®) NMR
- LSCMMG: Opioid reduction: best interests opioid reduction position statement
- LSCMMG: OpioId treatment: patient-prescriber opioid treatment agreement
- LSCMMG: Restless Legs Syndrome in Adults in Primary Care
- LSCMMG: Sodium Oxybate NMR
- MHRA Drug Safety Update March 2020: Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression
- MHRA Drug Safety Update Oct 2021:Chloral hydrate, cloral betaine (Welldorm): restriction of paediatric indication
- MHRA: Changes to drug driving law
- MHRA: Chloral hydrate, cloral betaine (Welldorm): restriction of paediatric indication
- MHRA: Drugs and driving: blood concentration limits to be set for certain controlled drugs in a new legal offence
- MHRA: Risk of drowsiness and reduced driving ability
- MHRA: Zolpidem: risk of drowsiness and reduced driving ability
- NICE Evidence summary: Melatonin for sleep disorders in children with ADHD
- NICE NG10: Violence and aggression: short-term management in mental health, health and community settings
- NICE NG215: Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adults
- NICE TA77: Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia
- NICE TA77: Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia
- NICE TA77: Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia
- NICE TA922: Daridorexant for treating long-term insomnia
- NICE TAG 77 : Zaleplon, zolpidem and zopiclone for the management of insomnia
- NICE TAG 77 :Zaleplon, zolpidem and zopiclone for the management of insomnia