Lancashire and South Cumbria
Formulary
Formulary
4 Central nervous system
04-10-03 Opioid substitution therapy
| Methadone |
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Formulary
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Oral solution 1mg/ml Under expert supervision. ECG monitoring recommended in patients with risk factors for QT-interval prolongation. |
 NICE TA114: Methadone and buprenorphine for the management of opioid dependence |
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| Buprenorphine |
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Formulary
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First line - Sublingual tablets 400micrograms, 2mg, 8mg Second line - Oral lyophilisates 2mg, 8mg (Espranor®)
Espranor® oral lyophilisate has different bioavailability to other buprenorphine products and is not interchangeable with them—consult product literature before switching between products.
Third line - Prolonged-release solution for injection pre-filled syringes (Buvidal®)
Buvidal® injections are available in formulations that can be given weekly or monthly depending on the strength of the injection.
Under expert supervision. |
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NICE TA114: Methadone and buprenorphine for the management of opioid dependence |
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Links
Gabapentinoid (pregabalin and gabapentin):De-prescribing guidance for non-cancer pain in adults in primary care - LSCMMG Paracetamol – prescribing weight-adjusted paracetamol in adults in the community
- LSCMMG: ADHD combined adult and child shared care guideline
- LSCMMG: Opioid reduction: best interests opioid reduction position statement
- LSCMMG: Opioid treatment: patient-prescriber opioid treatment agreement
- LSCMMG: Restless Legs Syndrome in Adults in Primary Care
- MHRA Drug Safety Update Jan 2020: E-cigarette use or vaping: reporting suspected adverse reactions, including lung injury
- MHRA: Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression
- MHRA: Opioids: risk of dependence and addiction
- NICE CG52: Drug misuse in over 16s: opioid detoxification
- NICE TA114: Methadone and buprenorphine for the management of opioid dependence
- NICE TA114: Methadone and buprenorphine for the management of opioid dependence
- NICE TA114: Methadone and buprenorphine for the management of opioid dependence
- NICE TA114: Methadone and buprenorphine for the management of opioid dependence
- NICE TA115: Drug misuse - naltrexone
- NICE TA115: Naltrexone for the management of opioid dependence