Lancashire and South Cumbria
Formulary
 
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6 Endocrine system
06-01-02-03 SGLT2 inhibitors

Canagliflozin Invokana®
Formulary

Tablets 100mg, 300mg

First line gliflozin

Link  MHRA Drug Safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety Update April 2016: SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
Link  MHRA Drug Safety Update March 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA315: Canagliflozin in combination therapy for treating type 2 diabetes
Link  NICE TA390: Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes

Green View adult BNF  View SPC online  View childrens BNF
Dapagliflozin
Formulary

Tablets 5mg, 10mg

First line gliflozin

Green ICB commissioned for NICE TA1075 Dapagliflozin for treating chronic kidney disease.

Link  NICE TA1075: Dapagliflozin for treating chronic kidney disease
Link  MHRA Drug safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety Update April 2016: SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
Link  MHRA Drug Safety Update December 2021: Dapagliflozin (Forxiga): no longer authorised for treatment of type 1 diabetes mellitus
Link  MHRA Drug Safety Update March 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA288: Dapagliflozin in combination therapy for treating type 2 diabetes
Link  NICE TA390: Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes
Link  NICE TA418: Dapagliflozin in triple therapy for treating type 2 diabetes

Green View adult BNF  View SPC online  View childrens BNF
Empagliflozin Jardiance®
Formulary

Tablets 10mg, 25 mg

First line gliflozin

Link  MHRA Drug Safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety Update April 2016: SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
Link  MHRA Drug Safety UpdateMarch 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA336: Empagliflozin in combination therapy for treating type 2 diabetes
Link  NICE TA390: Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes
Link  NICE TA942: Empagliflozin for treating chronic kidney disease

Green View adult BNF  View SPC online  View childrens BNF
Ertugliflozin  Steglatro®
Formulary

Tablets 5mg, 15mg

Restriction - only to be used as second line

 

Link  MHRA Drug Safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety update June 2015: SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin): risk of diabetic ketoacidosis
Link  MHRA Drug Safety Update March 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA572: Ertugliflozin as monotherapy or with metformin for treating type 2 diabetes

Green Restricted View adult BNF  View SPC online  View childrens BNF
Canagliflozin / metformin IR Vokanamet
Formulary

Do Not Prescribe View adult BNF  View SPC online  View childrens BNF