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 Formulary Chapter 11: Eye - Full Chapter
Notes:

This chapter of the formulary is under continual development, please let the team know if you have any comments about the contents: mlcsu.lscformulary@nhs.net

For more information about the formulary development process, please see: https://www.lancsmmg.nhs.uk/lancashire-and-south-cumbria-icb-formulary-development/

Chapter Links...
 Details...
11.01  Administration of drugs to the eye
 note 

The Drug Tariff only lists the five eye drop dispensers below:

ComplEye, EyGuide, Opticare, Opticare Arthro 5, Opticare Arthro 10   

Other products cannot be prescribed on NHS FP10 prescriptions. Eye drop dispensers are classed as medical appliances and therefore must be included in Part IXA of the Drug Tariff to be allowable on an NHS prescription. Other eye drops dispensers are available, but cannot be prescribed on NHS prescriptions. When recommending eye drop dispensers it is important to ensure that the eye drops and the eye drop dispenser are compatible. They are particularly useful for the elderly, visually impaired, arthritic, or otherwise physically limited patients.

See BNF for general guide on administration of drugs to the eye
https://bnf.nice.org.uk/treatment-summaries/eye/
 

11.02  Control of microbial contamination
11.03  Anti-infective eye preparations
11.03.01  Antibacterials
 note 

A course length should always be indicated on the prescription.

Chloramphenicol
View adult BNF View SPC online View childrens BNF
Formulary

Green Eye drops 0.5%
Eye ointment 1%
Eye drops 0.5% preservative-free 10ml (only for use in patients with a documented allergy to preservatives)

Chloramphenicol 0.5% eye drops (in max. pack size 10 mL) and 1% eye ointment (in max. pack size 4 g) can be sold to the public for treatment of acute bacterial conjunctivitis in adults and children over 2 years; max. duration of treatment 5 days.

Red single unit dose 0.5%

 

First line.

 
Link  LSCMMG: Over the Counter Items that Should not be Routinely Prescribed in Primary Care Policy
Link  MHRA: Chloramphenicol eye drops containing borax or boric acid buffers: use in children younger than 2 years
 
Fusidic Acid
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 1% in gel basis (liquefies on contact with eye)
 
Second line

 
 
Ciprofloxacin
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 0.3%

 
 
Gentamicin
View adult BNF View SPC online View childrens BNF
Formulary

Green Eye/ear drops 0.3% (Second line ocular antibacterial)

Red Preservative free eye drops 1.5% (Unlicensed - consultant ophthalmologist use only)

 
 
Levofloxacin
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.5% (5mg/ml)

preservative-free eye drops 0.5% - reserved for patients with a documented allergy to preservatives or for intensive use. 

 
 
Ofloxacin
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.3%

 
 
Propamidine Isetionate (Brolene®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.1%

Specialist use only for treatment of acanthamoeba keratitis

 
 
Cefuroxime
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Eye drops 5%

Consultant ophthalmologist only.

 
 
Chlorhexidine 0.02%
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Eye drops 0.02%

Consultant ophthalmologist only.

 
Link  MHRA: All medical devices and medicinal products containing chlorhexidine - Risk of anaphylactic reaction due to chlorhexidine allergy
 
Polihexanide
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Eye drops 0.02%

Specialist use only for treatment of fusarium keratitis

Also known as polyhexamethylene biguanide (PHMB)

 
 
11.03.02  Antifungals to top
Amphotericin B
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Eye drops 0.15% preservative free

Specialist use only.

 
 
Clotrimazole drops
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Eye drops 1% preservative free

Specialist use only.

 
 
11.03.03  Antivirals
Aciclovir
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye ointment 3% (30mg/g)

For treatment of herpes simplex keratitis. Treatment should continue for at least 3 days after the healing is complete.

 
 
Ganciclovir 0.15% ophthalmic gel (Virgan®)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye gel 5g (1.5mg/g)

Treatment of acute herpetic keratitis (dendritic and geographic ulcers). Not licensed for use in children under 18 years of age.

Manufacturer advises women of childbearing potential should use effective contraception during treatment; men with partners of childbearing potential should be advised to use barrier contraception during and for at least 90 days after treatment.

 
 
11.04  Corticosteroids and other anti-inflammatory preparations
11.04.01  Corticosteroids
 note  Topical corticosteroids should normally only be used under expert supervision
Betametasone with Neomycin eye drops (Betnesol N®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops betamethasone 0.1%, neomycin 0.385%

 
 
Betamethasone eye drops
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye/ear/nose drops 0.1%

 
 
Dexamethasone eye drops
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.1%
Eye drops preservative free 0.1% - only to be prescribed for those patients with documented preservative allergy.

 
 
Dexamethasone intravitreal implant (Ozurdex®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq

Ozurdex® intravitreal implant 700micrograms in disposable applicator

 
Link  NICE TA229: Dexamethasone intravitreal implant for the treatment of macular oedema secondary to retinal vein occlusion
Link  NICE TA460: Adalimumab and dexamethasone for treating non-infectious uveitis
Link  NICE TA824: Dexamethasone intravitreal implant for treating diabetic macular oedema
 
Dexamethasone with Neomycin and Polymyxin B sulphate (Maxitrol®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops Dexamethasone 1 mg per 1 ml, Hypromellose 5 mg per 1 ml, Neomycin (as Neomycin sulfate) 3500 unit per 1 ml, Polymyxin B sulfate 6000 unit per 1 ml

Eye ointment Dexamethasone 1 mg per 1 gram, Neomycin (as Neomycin sulfate) 3500 unit per 1 gram, Polymyxin B sulfate 6000 unit per 1 gram

 
 
Dexamethasone with Tobramycin
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Formulary
Amber 0

Eye drops dexamethasone 1mg/ml, tobramycin 3mg/ml

 

 
 
Fluocinolone intravitreal implant (Iluvien®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq

Intravitreal implant 190micrograms in a disposable applicator

 
Link  NICE TA590: Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis
Link  NICE TA953: Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema
 
Fluorometholone (FML®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops fluoromethalone 0.1%

 
 
Hydrocortisone sodium phosphate eye drops (Softacort®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 3.35mg/ml (0.4ml unit dose)

Maximum course duration 2 weeks.

 
 
Loteprednol (Lotemax®)
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Formulary
Amber 0

Eye drops 0.5% (5mg/ml)

Restricted Item Restricted to second line use for the treatment of post operative inflammation following ocular surgery in patients who are at risk of corticosteroid induced raised intra-ocular pressure.

 
 
Prednisolone eye drops
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.5%
Unit dose eye drops preservative free 0.5% (only for patients with a documented allergy to preservatives)
Eye drops 1% (Pred Forte®)

 
 
Triamcinolone acetonide (Intracinol®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Intravitreal opthalmic suspension 40mg/ml

Specialist use only.

 
 
11.04.02  Other anti-inflammatory preparations
Sodium Cromoglicate
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 2%
Unit dose eye drops (preservative free) 2%

First line.

Can be sold to the public (maximum pack size 10mL) for the treatment of acute seasonal and perennial allergic conjunctivitis.

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
Link  LSCMMG: Over the Counter Items that Should not be Routinely Prescribed in Primary Care Policy
 
Olopatadine
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 1mg/mL (0.1%)

Second line.

Maximum use 4 months.

 
 
Ketotifen (Ketofall®, Zaditen®)
View adult BNF View childrens BNF
Formulary
Amber 0

Eye drops 250 micrograms/ml (Zaditen®)
Unit dose eye drops (preservative free) 250micrograms /ml (Ketofall®)

Should only be prescribed when:

  • a patient has tried at least 2 alternative eye preparations for seasonal allergic conjunctivitis
  • and/or the patient is sensitive to preservatives.
 
 
11.05  Mydriatics and cycloplegics to top
Phenylephrine with tropicamide (Mydriasert®)
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Formulary
Red

Ophthalmic insert phenylephrine hydrochloride 5.4 mg, Tropicamide 0.28 mg

 
Link  Safety Alert: Reports of Mydriasert pellets left in situ post cataract surgery
 
Tropicamide with phenylephrine and lidocaine (Mydrane®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Solution for injection - lidocaine hydrochloride 10mg/ml, phenylephrine hydrochloride 3.1mg/ml, tropicamide 200microgram/ml

 
 
11.05  Antimuscarinics
Atropine
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 1%
Unit dose eye drops (preservative free) 1% (Minims®)

 
 
Cyclopentolate
View adult BNF View SPC online View childrens BNF
Formulary

Green Eye drops 0.5%, 1%
Red Unit dose eye drops (preservative free) 0.5%, 1% (Minims®)

 
 
Tropicamide
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 0.5%, 1%  (Minims®)

 

 
 
11.05  Sympathomimetics
Phenylephrine Hydrochloride
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 2.5%, 10% (Minims®)

 
 
11.06  Treatment of glaucoma
 note  Treatment for glaucoma should be initiated by a consultant or specialist in ophthalmology, repeat prescriptions however should be provided in primary care.
11.06  Beta-blockers
 note  CSM advice: Beta-blockers, even those with cardioselectivity should be avoided in patients with asthma or a history of COPD unless no other alternative treatment is available - see BNF
Timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.25%, 0.5%
Unit dose eye drops 0.25% and 0.5% (preservative free)
Eye gel 0.25%, 0.5% (Timoptol LA®)

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

First line.

 
 
Betaxolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.25%, 0.5%
Unit dose eye drops (preservative free) 0.25%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

Second line.

 
 
Levobunolol (Betagan®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Unit dose eye drops (preservative free) 0.5%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
11.06  Prostaglandin analogues to top
Latanoprost
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0
Eye drops 0.005%
Unit dose eye drops (preservative free) 0.005%
Multidose eye drops (preservative free) 0.005% (Lotacryn)

Preservative free preparation only to be used for those patients with documented allergies to preservatives.
 
First choice.
 
Link  MHRA: Latanoprost (Xalatan): increased reporting of eye irritation since reformulation
 
Bimatoprost
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.01%, 0.03%
Unit dose eye drops (preservative free) 0.03%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Bimatoprost with Timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops bimatoprost 0.03% with timolol 0.5%
Unit dose eye drops (preservative free) bimatoprost 0.03% with timolol 0.5%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Latanoprost - Netarsudil eyedropsBlack Triangle (Roclanda®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Only to be used if a prostaglandin analogue alone and then a subsequent fixed -dose combination has not reduced IOP sufficiently or a fixed dose combination treatment containing beta-blockers is unsuitable.

 
Link  NICE TA1009: Latanoprost–netarsudil for previously treated primary open-angle glaucoma or ocular hypertension
 
Latanoprost with timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops latanoprost 0.005% with timolol 0.5%
Unit dose eye drops (preservative free) latanoprost 0.005% with timolol 0.5% (Fixapost®)

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Tafluprost (Saflutan®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.0015%
Unit dose eye drops 0.0015% (preservative free)

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Travoprost
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.004%

 
 
Travoprost with Timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Travoprost 0.004%/ timolol 0.5%

 
 
11.06  Sympathomimetics
Apraclonidine (Iopidine®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.5% 

 
 
Brimonidine Tartrate
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 0.2%

 
 
Brimonidine Tartrate with Timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops brimonidine 0.2% with timolol 0.5%

 
 
11.06  Carbonic anhydrase inhibitors and systemic drugs
Dorzolamide with Timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops dorzolamide 2% with timolol 0.5%
Unit dose eye drops (preservative free) dorzolamide 2% with timolol 0.5%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

First choice.

 
 
Dorzolomide
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 2%
Unit dose eye drops (preservative free) dorzolamide 2%

Preservative free preparation only to be used for those patients with documented allergies to preservatives

First choice.

 
 
Brinzolamide
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 1%

Second choice.

 
 
Brinzolamide with Timolol
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops brinzolamide 1% with timolol 0.5% 

Second choice.

 
 
Brinzolamide with brimonidine
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops brinzolamide 1% with brimonidine 0.2%

Third choice.

 
 
Acetazolamide
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Tablets 250mg

 
Link  MHRA: Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review
Link  MHRA: Antiepileptics: risk of suicidal thoughts and behaviour
 
Acetazolamide injection
View adult BNF View SPC online View childrens BNF
Formulary
Red

Injection 500mg

 
Link  MHRA: Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review
Link  MHRA: Antiepileptics: risk of suicidal thoughts and behaviour
 
11.06  Miotics
Pilocarpine
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0
Eye drops 1% 2%
Unit dose eye drops (preservative free) 2% (Minims®)
 
 
11.06  Prostaglandin and Rho Kinase Inhibitor dual therapy
11.07  Local anaesthetics to top
 note 

Used before surgery on the eye. Not to be used for the management of ocular symptoms.

Fluorescein with lidocaine (Minims®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) fluorescein 0.25% with lidocaine 4% 

 
 
Oxybuprocaine hydrochloride (Minims® )
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 0.4%

 
 
Proxymetacaine Hydrochloride (Minims®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 0.5%

 
 
Tetracaine Hydrochloride (Minims®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 1%

 
 
11.08  Miscellaneous ophthalmic preparations
Potassium ascorbate
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Eye drops 10%

 
 
11.08.01  Tear deficiency, ocular lubricants, and astringents
 note 

Ocular lubricants under normal circumstances should be purchased OTC.

Acetylcysteine (Ilube®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber 0

Eye drops 5%

Restricted Item For treatment of filamentary keratitis only

 
 
Carbomer 980 eye drops
(polyacrylic acid)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Liquid gel eye drops 0.2%
Unit dose liquid gel eye drops (preservative free) 0.2%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Carmellose
View adult BNF View SPC online View childrens BNF
Formulary
Green

Multidose / unit dose preservative free eye drops 0.5%, 1%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Hypromellose
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 0.3%
Preservative free eye drops 0.3%

Preservative free preparation only to be used for those patients with documented allergies to preservatives. 

 
 
Polyvinyl Alcohol
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 1.4%
Unit dose eye drops (preservative free) 1.4%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Sodium Chloride
View adult BNF View SPC online View childrens BNF
Formulary
Green

Unit dose eye drops (preservative free) 0.9% Minims® 
Eye drops 5%
Eye drops multidose / unit dose (preservative free) 5%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Sodium Hyaluronate
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye drops 0.2%
Eye drops (preservative free) 0.1%, 0.2%
Unit dose eye drops (preservative free) 0.1%, 0.2%
Eye drops (preservative free ) Sodium hyaluronate 0.15% and trehalose 3% (Thealoz Duo®)
Eye drops sodium hyaluronate 2% & tamarind seed polysaccharide 0.2% (Hydramed Night®)

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

The most cost effective option should be used.

 
 
White soft paraffin / Vitamin A 250IU/g (Hylo-night®)
(formerly known as VitA-Pos®)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Eye ointment preservative free

2nd line to Hydramed Night

 
 
11.08.02  Ocular diagnostic and peri-operative preparations and photodynamic treatment
11.08.02  Ocular diagnostic preparations
Fluorescein Sodium
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 1%, 2%
Injection 10% - For fluorescein angiography of the ocular fundus
Injection 20% (unlicensed product)

 
 
Indocyanine green
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Formulary
Red

Injection 25mg

 
 
Trypan Blue (Vision Blue®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Injection

For use in cataract surgery

 
 
11.08.02  Ocular peri-operative drugs to top
Acetylcholine Chloride (Miochol-E® Miphtel®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

20mg powder and solvent for solution for intraocular irrigation

 
 
Apraclonidine (Iopidine®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 1%

For perioperative use only.

 
 
Balanced Salt Solution
View adult BNF View SPC online View childrens BNF
Formulary
Red
Sterile irrigation solution 15mL, 500mL 
 
Bromfenac (Yellox®)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.09%

For treatment of postoperative ocular inflammation following cataract extraction.

 
 
Diclofenac (Voltarol® Ophtha)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.1%
Unit dose eye drops (preservative free) 0.1%

Preservative free preparation only to be used for those patients with documented allergies to preservatives.

 
 
Ketorolac
View adult BNF View SPC online View childrens BNF
Formulary
Red

Eye drops 0.5%

 
 
Povidone iodine
View adult BNF View SPC online View childrens BNF
Formulary
Red

Unit dose eye drops (preservative free) 5% single use only

 
 
Sodium hyaluronate
(Obtained from central stores)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Injection 1%
Injection prefilled syringe 15mg in 1mL
Injection prefilled syringe 14mg in 1mL (Haelon GV®)

 
 
Disodium edetate
(EDTA)
View adult BNF View SPC online View childrens BNF
Unlicensed Drug Unlicensed
Red

Preservative free solution 0.37%

 
 
11.08.02  Subfoveal choroidal neovascularisation
Aflibercept (Eylea®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq

Solution for intravitreal injection pre-filled syringe 40mg/mL
 

 
Link  MHRA: EYLEA 40 mg/mL (aflibercept solution for intravitreal injection): Higher risk of intraocular pressure increase with the pre-filled syringe
Link  NICE TA294: Aflibercept solution for injection for treating wet age‑related macular degeneration
Link  NICE TA305: Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion
Link  NICE TA346: Aflibercept for treating diabetic macular oedema
Link  NICE TA409: Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion
Link  NICE TA486: Aflibercept for treating choroidal neovascularisation
 
Brolucizumab Black Triangle (Beovu®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq

Solution for  intravitreal injection 19.8mg/0.165ml

 
Link  MHRA: Brolucizumab (Beovu▼): risk of intraocular inflammation and retinal vascular occlusion increased with short dosing intervals
Link  NICE TA672: Brolucizumab for treating wet age-related macular degeneration
Link  NICE TA820: Brolucizumab for treating diabetic macular oedema
 
FaricimabBlack Triangle (Vabysmo ®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
CCG
BlueTeq

Solution for intravitreal injection 120 mg/mL

 
Link  NICE TA1004: Faricimab for treating visual impairment caused by macular oedema after retinal vein occlusion
Link  NICE TA799: Faricimab for treating diabetic macular oedema
Link  NICE TA800: Faricimab for treating wet age-related macular degeneration
 
Ranibizumab
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq

Solution for intravitreal injection 10mg/mL

Ranibizumab biosimilars -  Black Triangle Byooviz, Ongavia, Rimmyrah and Ximluci

Do Not Prescribe  For NICE TA637: Ranibizumab for treating diabetic retinopathy (terminated appraisal).

 
Link  NICE TA155: Ranibizumab and pegaptanib for the treatment of age-related macular degeneration
Link  NICE TA274: Ranibizumab for treating diabetic macular oedema
Link  NICE TA283: Ranibizumab for treating visual impairment caused by macular oedema secondary to retinal vein occlusion
Link  NICE TA298: Ranibizumab for treating choroidal neovascularisation associated with pathological myopia
Link  NICE TA637: Ranibizumab for treating diabetic retinopathy (terminated appraisal)
 
Verteporfin injection
View adult BNF View SPC online View childrens BNF
Formulary
Red

Powder for solution for infusion 15mg

 
 
Bevacizumab gamma
View adult BNF View SPC online View childrens BNF
Formulary
Do Not Prescribe
 
Link  NICE TA1022: Bevacizumab gamma for treating wet age-related macular degeneration
 
Pegaptanib
View adult BNF View SPC online View childrens BNF
Formulary
Do Not Prescribe
 
Link  NICE TA155: Ranibizumab and pegaptanib for the treatment of age-related macular degeneration
 
11.08.02  Vitreomacular traction
11.08.02  Uveitis
Adalimumab
View adult BNF View SPC online View childrens BNF
Formulary
Red
NHS England
BlueTeq

Solution for injection

 
Link  MHRA: Tumour necrosis factor alpha inhibitors
Link  NICE TA460: Adalimumab and dexamethasone for treating non-infectious uveitis
 
11.08.03  Reduction of elevated intra-ocular pressure
11.09  Contact lenses to top
 note  See BNF
11.10  Additional treatments used in the management of ophthalmic conditions not listed in BNF chapter 11
11.11  Miscellaneous
11.11  Antifungals
11.11  Cytotoxics / wound healing modulators
11.11  Fibrinolytic drugs to top
11.11  Glues - ocular
11.11  Immunosuppressants
Ciclosporin 0.1% eye drops
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Amber 0

Unit dose eye drops emulsion 0.1% (Ikervis) - For adult patients

Unit dose eye drops emulsion 0.1% (Verkazia) - For children and adolescents

 
Link  LSCMMG: Ciclosporin 0.1% / 1 mg/mL eye drops
Link  NICE TA369: Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tears
 
11.11  Treatment of burns
11.11  Visco-elastics
11.11  Other to top
HoloclarBlack Triangle
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Red
High Cost Medicine

79,000 - 316,000 cells/cm2 living tissue equivalent

 
Link  NICE TA467: Holoclar for treating limbal stem cell deficiency after eye burns
 
Mercaptamine (Cysteamine®)
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Red

For the treatment of corneal cystine crystal deposits in adults and children from 2 years of age with cystinosis.

 
 
Voretigene NeparvovecBlack Triangle (Luxturna®)
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Red
High Cost Medicine
NHS England
BlueTeq

Tertiary Centre only

 
Link  NICE: Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations
 
Lutein and Antioxidants
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Do Not Prescribe
 
Link  LSCMMG: Over the Counter Items that Should not be Routinely Prescribed in Primary Care Policy
 
 ....
Key
Restricted Drug Restricted Drug
Unlicensed Drug Unlicensed
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
ICB
Green Low Carbon

Low carbon footprint

Amber Medium Carbon

Medium carbon footprint

Red High carbon footprint

High carbon footprint

Status Description

Green

Green: Appropriate for initiation and ongoing prescribing in both primary and secondary care. Generally, little or no routine drug monitoring is required.  

Green Restricted

Green (Restricted): Appropriate for initiation and ongoing prescribing in both primary and secondary care provided: Additional criteria specific to the medicine or device are met, or The medicine or device is used following the failure of other therapies as defined by the relevant LSCMMG pathway. Generally, little or no routine drug monitoring is required.   

Red

Red medicines: Medicine is supplied by the hospital for the duration of the treatment course. Primary care initiation or continuation of treatment is not recommended unless exceptional circumstances such as specialist GP. Red medicines are those where primary care prescribing is not recommended. These treatments should be initiated by specialists only and prescribing retained within secondary care. They require specialist knowledge, intensive monitoring, specific dose adjustments or further evaluation in use. If however, a primary care prescriber has particular specialist knowledge or experience of prescribing a particular drug for a particular patient it would not always be appropriate for them to expect to transfer that prescribing responsibility back to secondary care. There should be a specific reason and a specific risk agreement, protocol and service set up to support this. Primary care prescribers may prescribe RED medicines in exceptional circumstances to patients to ensure continuity of supply while arrangements are made to obtain ongoing supplies from secondary care.  

Amber 0

Amber level 0: Suitable for prescribing in primary care following recommendation or initiation by a specialist. Little or no specific monitoring required. Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care. Brief prescribing document or information sheet may be required. Primary care prescribers must be familiar with the drug to take on prescribing responsibility or must get the required information. When recommending or handing over care, specialists should ask primary care prescribers to take over prescribing responsibility, and should give enough information about the indication, dose, monitoring requirements, use outside product licence and any necessary dose adjustments to allow them to confidently prescribe.  

Amber 1

Amber level 1 (with shared care): Suitable for prescribing in primary care following recommendation or initiation by a specialist. Minimal monitoring required. Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care. Full prior agreement about patient’s on-going care must be reached under the shared care agreement. Primary care prescribers are advised not to take on prescribing of these medicines unless they have been adequately informed by letter of their responsibilities with regards monitoring, side effects and interactions and are happy to take on the prescribing responsibility. A copy of locally approved shared care guidelines should accompany this letter which outlines these responsibilities. Primary care prescribers should then tell secondary care of their intentions as soon as possible by letter so that arrangements can be made for the transfer of care.  

Amber 2

Amber level 2 (with shared care and enhanced service): Initiated by specialist and transferred to primary care following a successful initiation period. Significant monitoring required on an on-going basis. Full prior agreement about patient’s on-going care must be reached under the shared care agreement. Suitable for enhanced service. These medicines are considered suitable for GP prescribing following specialist initiation of therapy, as per shared care document which will be sent out with the request to prescribe, with on-going communication between the primary care prescriber and specialist. Amber Level 2 medicines require significant monitoring for which an enhanced service may be suitable. (Subject to local commissioning agreements).  

Do Not Prescribe

Do not prescribe: NOT recommended for use by the NHS in Lancashire and South Cumbria. Includes medicines that NICE has not recommended for use and terminated technology appraisals, unless there is a local need.  

Grey

Grey medicines: Medicines which have not yet been reviewed or are under the review process. GPs and specialists are recommended not to prescribe these drugs. This category includes drugs where funding has not yet been agreed.   

Multiple

Refer to local guidance.  

netFormulary