Formulary Chapter 11: Eye - Full Chapter
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Notes: |
This chapter of the formulary is under continual development, please let the team know if you have any comments about the contents: mlcsu.lscformulary@nhs.net.
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Chapter Links... |
NICE NG242: Diabetic retinopathy: management and monitoring |
NICE NG77: Cataracts in adults: management |
NICE NG81: Glaucoma: diagnosis and management |
NICE NG82: Age-related macular degeneration |
Details... |
11.01 |
Administration of drugs to the eye |
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The Drug Tariff only lists the five eye drop dispensers below:
ComplEye, EyGuide, Opticare, Opticare Arthro 5, Opticare Arthro 10
Other products cannot be prescribed on NHS FP10 prescriptions. Eye drop dispensers are classed as medical appliances and therefore must be included in Part IXA of the Drug Tariff to be allowable on an NHS prescription. Other eye drops dispensers are available, but cannot be prescribed on NHS prescriptions. When recommending eye drop dispensers it is important to ensure that the eye drops and the eye drop dispenser are compatible. They are particularly useful for the elderly, visually impaired, arthritic, or otherwise physically limited patients.
See BNF for general guide on administration of drugs to the eye https://bnf.nice.org.uk/treatment-summaries/eye/ |
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11.02 |
Control of microbial contamination |
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11.03 |
Anti-infective eye preparations |
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A course length should always be indicated on the prescription. |
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Chloramphenicol
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Formulary
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Eye drops 0.5% Eye ointment 1% Eye drops 0.5% preservative-free 10ml (only for use in patients with a documented allergy to preservatives)
Chloramphenicol 0.5% eye drops (in max. pack size 10 mL) and 1% eye ointment (in max. pack size 4 g) can be sold to the public for treatment of acute bacterial conjunctivitis in adults and children over 2 years; max. duration of treatment 5 days.
single unit dose 0.5%
First line.
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LSCMMG: Over the Counter Items that Should not be Routinely Prescribed in Primary Care Policy
MHRA: Chloramphenicol eye drops containing borax or boric acid buffers: use in children younger than 2 years
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Fusidic Acid
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Formulary
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Eye drops 1% in gel basis (liquefies on contact with eye) Second line
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Ciprofloxacin
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Formulary
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Eye drops 0.3%
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Gentamicin
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Formulary
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Eye/ear drops 0.3% (Second line ocular antibacterial)
Preservative free eye drops 1.5% (Unlicensed - consultant ophthalmologist use only)
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Levofloxacin
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Formulary
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Eye drops 0.5% (5mg/ml)
preservative-free eye drops 0.5% - reserved for patients with a documented allergy to preservatives or for intensive use.
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Ofloxacin
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Formulary
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Eye drops 0.3%
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Propamidine Isetionate (Brolene®)
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Formulary
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Eye drops 0.1%
Specialist use only for treatment of acanthamoeba keratitis
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Cefuroxime
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Unlicensed
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Eye drops 5% Consultant ophthalmologist only.
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Chlorhexidine 0.02%
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Unlicensed
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Eye drops 0.02%
Consultant ophthalmologist only.
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MHRA: All medical devices and medicinal products containing chlorhexidine - Risk of anaphylactic reaction due to chlorhexidine allergy
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Polihexanide
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Unlicensed
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Eye drops 0.02%
Specialist use only for treatment of fusarium keratitis
Also known as polyhexamethylene biguanide (PHMB)
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11.03.02 |
Antifungals |
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Amphotericin B
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Unlicensed
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Eye drops 0.15% preservative free
Specialist use only.
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Clotrimazole drops
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Unlicensed
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Eye drops 1% preservative free
Specialist use only.
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Aciclovir
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Formulary
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Eye ointment 3% (30mg/g)
For treatment of herpes simplex keratitis. Treatment should continue for at least 3 days after the healing is complete.
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Ganciclovir 0.15% ophthalmic gel (Virgan®)
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Formulary
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Eye gel 5g (1.5mg/g)
Treatment of acute herpetic keratitis (dendritic and geographic ulcers). Not licensed for use in children under 18 years of age.
Manufacturer advises women of childbearing potential should use effective contraception during treatment; men with partners of childbearing potential should be advised to use barrier contraception during and for at least 90 days after treatment.
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11.04 |
Corticosteroids and other anti-inflammatory preparations |
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Topical corticosteroids should normally only be used under expert supervision |
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Betametasone with Neomycin eye drops (Betnesol N®)
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Formulary
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Eye drops betamethasone 0.1%, neomycin 0.385%
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Betamethasone eye drops
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Formulary
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Eye/ear/nose drops 0.1%
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Dexamethasone eye drops
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Formulary
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Eye drops 0.1% Eye drops preservative free 0.1% - only to be prescribed for those patients with documented preservative allergy.
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Dexamethasone intravitreal implant (Ozurdex®)
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Formulary

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Ozurdex® intravitreal implant 700micrograms in disposable applicator
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NICE TA229: Dexamethasone intravitreal implant for the treatment of macular oedema secondary to retinal vein occlusion
NICE TA460: Adalimumab and dexamethasone for treating non-infectious uveitis
NICE TA824: Dexamethasone intravitreal implant for treating diabetic macular oedema
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Dexamethasone with Neomycin and Polymyxin B sulphate (Maxitrol®)
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Formulary
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Eye drops Dexamethasone 1 mg per 1 ml, Hypromellose 5 mg per 1 ml, Neomycin (as Neomycin sulfate) 3500 unit per 1 ml, Polymyxin B sulfate 6000 unit per 1 ml
Eye ointment Dexamethasone 1 mg per 1 gram, Neomycin (as Neomycin sulfate) 3500 unit per 1 gram, Polymyxin B sulfate 6000 unit per 1 gram
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Dexamethasone with Tobramycin
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Formulary
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Eye drops dexamethasone 1mg/ml, tobramycin 3mg/ml
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Fluocinolone intravitreal implant (Iluvien®)
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Formulary

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Intravitreal implant 190micrograms in a disposable applicator
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NICE TA590: Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis
NICE TA953: Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema
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Fluorometholone (FML®)
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Formulary
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Eye drops fluoromethalone 0.1%
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Hydrocortisone sodium phosphate eye drops (Softacort®)
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Formulary
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Eye drops 3.35mg/ml (0.4ml unit dose)
Maximum course duration 2 weeks.
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Loteprednol (Lotemax®)
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Formulary
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Eye drops 0.5% (5mg/ml)
Restricted to second line use for the treatment of post operative inflammation following ocular surgery in patients who are at risk of corticosteroid induced raised intra-ocular pressure.
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Prednisolone eye drops
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Formulary
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Eye drops 0.5% Unit dose eye drops preservative free 0.5% (only for patients with a documented allergy to preservatives) Eye drops 1% (Pred Forte®)
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Triamcinolone acetonide (Intracinol®)
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Formulary
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Intravitreal opthalmic suspension 40mg/ml
Specialist use only.
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11.04.02 |
Other anti-inflammatory preparations |
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Sodium Cromoglicate
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Formulary
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Eye drops 2% Unit dose eye drops (preservative free) 2%
First line.
Can be sold to the public (maximum pack size 10mL) for the treatment of acute seasonal and perennial allergic conjunctivitis.
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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LSCMMG: Over the Counter Items that Should not be Routinely Prescribed in Primary Care Policy
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Olopatadine
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Formulary
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Eye drops 1mg/mL (0.1%)
Second line.
Maximum use 4 months.
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Ketotifen (Ketofall®, Zaditen®)
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Formulary
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Eye drops 250 micrograms/ml (Zaditen®) Unit dose eye drops (preservative free) 250micrograms /ml (Ketofall®)
Should only be prescribed when:
- a patient has tried at least 2 alternative eye preparations for seasonal allergic conjunctivitis
- and/or the patient is sensitive to preservatives.
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11.05 |
Mydriatics and cycloplegics |
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Phenylephrine with tropicamide (Mydriasert®)
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Formulary
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Ophthalmic insert phenylephrine hydrochloride 5.4 mg, Tropicamide 0.28 mg
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Safety Alert: Reports of Mydriasert pellets left in situ post cataract surgery
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Tropicamide with phenylephrine and lidocaine (Mydrane®)
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Formulary
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Solution for injection - lidocaine hydrochloride 10mg/ml, phenylephrine hydrochloride 3.1mg/ml, tropicamide 200microgram/ml
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Atropine
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Formulary
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Eye drops 1% Unit dose eye drops (preservative free) 1% (Minims®)
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Cyclopentolate
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Formulary
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Eye drops 0.5%, 1%
Unit dose eye drops (preservative free) 0.5%, 1% (Minims®)
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Tropicamide
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Formulary
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Unit dose eye drops (preservative free) 0.5%, 1% (Minims®)
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Phenylephrine Hydrochloride
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Formulary
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Unit dose eye drops (preservative free) 2.5%, 10% (Minims®)
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11.06 |
Treatment of glaucoma |
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Treatment for glaucoma should be initiated by a consultant or specialist in ophthalmology, repeat prescriptions however should be provided in primary care. |
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CSM advice: Beta-blockers, even those with cardioselectivity should be avoided in patients with asthma or a history of COPD unless no other alternative treatment is available - see BNF |
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Timolol
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Formulary
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Eye drops 0.25%, 0.5% Unit dose eye drops 0.25% and 0.5% (preservative free) Eye gel 0.25%, 0.5% (Timoptol LA®)
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
First line.
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Betaxolol
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Formulary
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Eye drops 0.25%, 0.5% Unit dose eye drops (preservative free) 0.25%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
Second line.
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Levobunolol (Betagan®)
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Formulary
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Unit dose eye drops (preservative free) 0.5%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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11.06 |
Prostaglandin analogues |
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Latanoprost
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Formulary
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Eye drops 0.005% Unit dose eye drops (preservative free) 0.005% Multidose eye drops (preservative free) 0.005% (Lotacryn)
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
First choice.
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MHRA: Latanoprost (Xalatan): increased reporting of eye irritation since reformulation
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Bimatoprost
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Formulary
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Eye drops 0.01%, 0.03% Unit dose eye drops (preservative free) 0.03%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Bimatoprost with Timolol
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Formulary
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Eye drops bimatoprost 0.03% with timolol 0.5% Unit dose eye drops (preservative free) bimatoprost 0.03% with timolol 0.5%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Latanoprost - Netarsudil eyedrops (Roclanda®)
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Formulary
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Only to be used if a prostaglandin analogue alone and then a subsequent fixed -dose combination has not reduced IOP sufficiently or a fixed dose combination treatment containing beta-blockers is unsuitable.
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NICE TA1009: Latanoprost–netarsudil for previously treated primary open-angle glaucoma or ocular hypertension
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Latanoprost with timolol
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Formulary
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Eye drops latanoprost 0.005% with timolol 0.5% Unit dose eye drops (preservative free) latanoprost 0.005% with timolol 0.5% (Fixapost®)
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Tafluprost (Saflutan®)
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Formulary
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Eye drops 0.0015% Unit dose eye drops 0.0015% (preservative free)
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Travoprost
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Formulary
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Eye drops 0.004%
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Travoprost with Timolol
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Formulary
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Travoprost 0.004%/ timolol 0.5%
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Apraclonidine (Iopidine®)
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Formulary
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Eye drops 0.5%
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Brimonidine Tartrate
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Formulary
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Eye drops 0.2%
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Brimonidine Tartrate with Timolol
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Formulary
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Eye drops brimonidine 0.2% with timolol 0.5%
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11.06 |
Carbonic anhydrase inhibitors and systemic drugs |
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Dorzolamide with Timolol
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Formulary
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Eye drops dorzolamide 2% with timolol 0.5% Unit dose eye drops (preservative free) dorzolamide 2% with timolol 0.5%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
First choice.
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Dorzolomide
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Formulary
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Eye drops 2% Unit dose eye drops (preservative free) dorzolamide 2%
Preservative free preparation only to be used for those patients with documented allergies to preservatives
First choice.
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Brinzolamide
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Formulary
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Eye drops 1%
Second choice.
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Brinzolamide with Timolol
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Formulary
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Eye drops brinzolamide 1% with timolol 0.5%
Second choice.
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Brinzolamide with brimonidine
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Formulary
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Eye drops brinzolamide 1% with brimonidine 0.2%
Third choice.
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Acetazolamide
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Formulary
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Tablets 250mg
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MHRA: Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review
MHRA: Antiepileptics: risk of suicidal thoughts and behaviour
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Acetazolamide injection
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Formulary
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Injection 500mg
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MHRA: Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review
MHRA: Antiepileptics: risk of suicidal thoughts and behaviour
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Pilocarpine
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Formulary
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Eye drops 1% 2%
Unit dose eye drops (preservative free) 2% (Minims®)
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11.06 |
Prostaglandin and Rho Kinase Inhibitor dual therapy |
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11.07 |
Local anaesthetics |
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Used before surgery on the eye. Not to be used for the management of ocular symptoms. |
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Fluorescein with lidocaine (Minims®)
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Formulary
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Unit dose eye drops (preservative free) fluorescein 0.25% with lidocaine 4%
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Oxybuprocaine hydrochloride (Minims® )
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Formulary
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Unit dose eye drops (preservative free) 0.4%
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Proxymetacaine Hydrochloride (Minims®)
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Formulary
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Unit dose eye drops (preservative free) 0.5%
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Tetracaine Hydrochloride (Minims®)
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Formulary
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Unit dose eye drops (preservative free) 1%
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11.08 |
Miscellaneous ophthalmic preparations |
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Potassium ascorbate
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Unlicensed
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Eye drops 10%
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11.08.01 |
Tear deficiency, ocular lubricants, and astringents |
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Ocular lubricants under normal circumstances should be purchased OTC. |
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Acetylcysteine (Ilube®)
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Formulary
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Eye drops 5%
For treatment of filamentary keratitis only
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Carbomer 980 eye drops (polyacrylic acid)
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Formulary
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Liquid gel eye drops 0.2% Unit dose liquid gel eye drops (preservative free) 0.2%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Carmellose
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Formulary
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Multidose / unit dose preservative free eye drops 0.5%, 1%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Hypromellose
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Formulary
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Eye drops 0.3% Preservative free eye drops 0.3%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Polyvinyl Alcohol
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Formulary
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Eye drops 1.4% Unit dose eye drops (preservative free) 1.4%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Sodium Chloride
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Formulary
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Unit dose eye drops (preservative free) 0.9% Minims® Eye drops 5% Eye drops multidose / unit dose (preservative free) 5%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Sodium Hyaluronate
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Formulary
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Eye drops 0.2% Eye drops (preservative free) 0.1%, 0.2% Unit dose eye drops (preservative free) 0.1%, 0.2% Eye drops (preservative free ) Sodium hyaluronate 0.15% and trehalose 3% (Thealoz Duo®) Eye drops sodium hyaluronate 2% & tamarind seed polysaccharide 0.2% (Hydramed Night®)
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
The most cost effective option should be used.
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White soft paraffin / Vitamin A 250IU/g (Hylo-night®) (formerly known as VitA-Pos®)
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Formulary
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Eye ointment preservative free
2nd line to Hydramed Night
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11.08.02 |
Ocular diagnostic and peri-operative preparations and photodynamic treatment |
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11.08.02 |
Ocular diagnostic preparations |
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Fluorescein Sodium
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Formulary
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Unit dose eye drops (preservative free) 1%, 2% Injection 10% - For fluorescein angiography of the ocular fundus Injection 20% (unlicensed product)
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Indocyanine green
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Formulary
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Injection 25mg
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Trypan Blue (Vision Blue®)
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Formulary
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Injection
For use in cataract surgery
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11.08.02 |
Ocular peri-operative drugs |
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Acetylcholine Chloride (Miochol-E® Miphtel®)
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Formulary
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20mg powder and solvent for solution for intraocular irrigation
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Apraclonidine (Iopidine®)
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Formulary
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Unit dose eye drops (preservative free) 1%
For perioperative use only.
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Balanced Salt Solution
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Formulary
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Sterile irrigation solution 15mL, 500mL
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Bromfenac (Yellox®)
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Formulary
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Eye drops 0.09%
For treatment of postoperative ocular inflammation following cataract extraction.
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Diclofenac (Voltarol® Ophtha)
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Formulary
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Eye drops 0.1% Unit dose eye drops (preservative free) 0.1%
Preservative free preparation only to be used for those patients with documented allergies to preservatives.
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Ketorolac
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Formulary
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Eye drops 0.5%
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Povidone iodine
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Formulary
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Unit dose eye drops (preservative free) 5% single use only
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Sodium hyaluronate (Obtained from central stores)
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Formulary
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Injection 1% Injection prefilled syringe 15mg in 1mL Injection prefilled syringe 14mg in 1mL (Haelon GV®)
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Disodium edetate (EDTA)
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Unlicensed
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Preservative free solution 0.37%
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11.08.02 |
Subfoveal choroidal neovascularisation |
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Aflibercept (Eylea®)
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Formulary

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Solution for intravitreal injection pre-filled syringe 40mg/mL
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MHRA: EYLEA 40 mg/mL (aflibercept solution for intravitreal injection): Higher risk of intraocular pressure increase with the pre-filled syringe
NICE TA294: Aflibercept solution for injection for treating wet age‑related macular degeneration
NICE TA305: Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion
NICE TA346: Aflibercept for treating diabetic macular oedema
NICE TA409: Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion
NICE TA486: Aflibercept for treating choroidal neovascularisation
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Brolucizumab (Beovu®)
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Formulary

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Solution for intravitreal injection 19.8mg/0.165ml
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MHRA: Brolucizumab (Beovu▼): risk of intraocular inflammation and retinal vascular occlusion increased with short dosing intervals
NICE TA672: Brolucizumab for treating wet age-related macular degeneration
NICE TA820: Brolucizumab for treating diabetic macular oedema
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Faricimab (Vabysmo ®)
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Formulary


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Solution for intravitreal injection 120 mg/mL
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NICE TA1004: Faricimab for treating visual impairment caused by macular oedema after retinal vein occlusion
NICE TA799: Faricimab for treating diabetic macular oedema
NICE TA800: Faricimab for treating wet age-related macular degeneration
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Ranibizumab
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Formulary

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Solution for intravitreal injection 10mg/mL
Ranibizumab biosimilars - Byooviz, Ongavia, Rimmyrah and Ximluci
For NICE TA637: Ranibizumab for treating diabetic retinopathy (terminated appraisal).
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NICE TA155: Ranibizumab and pegaptanib for the treatment of age-related macular degeneration
NICE TA274: Ranibizumab for treating diabetic macular oedema
NICE TA283: Ranibizumab for treating visual impairment caused by macular oedema secondary to retinal vein occlusion
NICE TA298: Ranibizumab for treating choroidal neovascularisation associated with pathological myopia
NICE TA637: Ranibizumab for treating diabetic retinopathy (terminated appraisal)
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Verteporfin injection
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Formulary
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Powder for solution for infusion 15mg
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Bevacizumab gamma
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Formulary
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NICE TA1022: Bevacizumab gamma for treating wet age-related macular degeneration
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Pegaptanib
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Formulary
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NICE TA155: Ranibizumab and pegaptanib for the treatment of age-related macular degeneration
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11.08.02 |
Vitreomacular traction |
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Adalimumab
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Formulary

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Solution for injection
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MHRA: Tumour necrosis factor alpha inhibitors
NICE TA460: Adalimumab and dexamethasone for treating non-infectious uveitis
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11.08.03 |
Reduction of elevated intra-ocular pressure |
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11.09 |
Contact lenses |
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See BNF |
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11.10 |
Additional treatments used in the management of ophthalmic conditions not listed in BNF chapter 11 |
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11.11 |
Cytotoxics / wound healing modulators |
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11.11 |
Fibrinolytic drugs |
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Ciclosporin 0.1% eye drops
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Formulary
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Unit dose eye drops emulsion 0.1% (Ikervis) - For adult patients
Unit dose eye drops emulsion 0.1% (Verkazia) - For children and adolescents
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LSCMMG: Ciclosporin 0.1% / 1 mg/mL eye drops
NICE TA369: Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tears
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11.11 |
Other |
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Holoclar
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Formulary
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79,000 - 316,000 cells/cm2 living tissue equivalent
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NICE TA467: Holoclar for treating limbal stem cell deficiency after eye burns
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Mercaptamine (Cysteamine®)
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Formulary
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For the treatment of corneal cystine crystal deposits in adults and children from 2 years of age with cystinosis.
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Voretigene Neparvovec (Luxturna®)
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Formulary


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Tertiary Centre only
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NICE: Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations
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Lutein and Antioxidants
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Formulary
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LSCMMG: Over the Counter Items that Should not be Routinely Prescribed in Primary Care Policy
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.... |
Key |
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Restricted Drug |
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Unlicensed |
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
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Scottish Medicines Consortium |
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Cytotoxic Drug |
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Controlled Drug |
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High Cost Medicine |
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Cancer Drugs Fund |
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NHS England |
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Homecare |
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ICB |
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Low carbon footprint |
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Medium carbon footprint |
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High carbon footprint |
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Status |
Description |

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Green:
Appropriate for initiation and ongoing prescribing in both primary and secondary care.
Generally, little or no routine drug monitoring is required. |

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Green (Restricted):
Appropriate for initiation and ongoing prescribing in both primary and secondary care provided:
Additional criteria specific to the medicine or device are met, or
The medicine or device is used following the failure of other therapies as defined by the relevant LSCMMG pathway.
Generally, little or no routine drug monitoring is required.
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Red medicines:
Medicine is supplied by the hospital for the duration of the treatment course.
Primary care initiation or continuation of treatment is not recommended unless exceptional circumstances such as specialist GP.
Red medicines are those where primary care prescribing is not recommended. These treatments should be initiated by specialists only and prescribing retained within secondary care. They require specialist knowledge, intensive monitoring, specific dose adjustments or further evaluation in use. If however, a primary care prescriber has particular specialist knowledge or experience of prescribing a particular drug for a particular patient it would not always be appropriate for them to expect to transfer that prescribing responsibility back to secondary care. There should be a specific reason and a specific risk agreement, protocol and service set up to support this.
Primary care prescribers may prescribe RED medicines in exceptional circumstances to patients to ensure continuity of supply while arrangements are made to obtain ongoing supplies from secondary care. |

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Amber level 0:
Suitable for prescribing in primary care following recommendation or initiation by a specialist.
Little or no specific monitoring required.
Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care.
Brief prescribing document or information sheet may be required.
Primary care prescribers must be familiar with the drug to take on prescribing responsibility or must get the required information.
When recommending or handing over care, specialists should ask primary care prescribers to take over prescribing responsibility, and should give enough information about the indication, dose, monitoring requirements, use outside product licence and any necessary dose adjustments to allow them to confidently prescribe. |

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Amber level 1 (with shared care):
Suitable for prescribing in primary care following recommendation or initiation by a specialist.
Minimal monitoring required.
Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care.
Full prior agreement about patient’s on-going care must be reached under the shared care agreement.
Primary care prescribers are advised not to take on prescribing of these medicines unless they have been adequately informed by letter of their responsibilities with regards monitoring, side effects and interactions and are happy to take on the prescribing responsibility. A copy of locally approved shared care guidelines should accompany this letter which outlines these responsibilities. Primary care prescribers should then tell secondary care of their intentions as soon as possible by letter so that arrangements can be made for the transfer of care. |

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Amber level 2 (with shared care and enhanced service):
Initiated by specialist and transferred to primary care following a successful initiation period.
Significant monitoring required on an on-going basis.
Full prior agreement about patient’s on-going care must be reached under the shared care agreement.
Suitable for enhanced service.
These medicines are considered suitable for GP prescribing following specialist initiation of therapy, as per shared care document which will be sent out with the request to prescribe, with on-going communication between the primary care prescriber and specialist. Amber Level 2 medicines require significant monitoring for which an enhanced service may be suitable. (Subject to local commissioning agreements). |

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Do not prescribe: NOT recommended for use by the NHS in Lancashire and South Cumbria.
Includes medicines that NICE has not recommended for use and terminated technology appraisals, unless there is a local need. |

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Grey medicines:
Medicines which have not yet been reviewed or are under the review process.
GPs and specialists are recommended not to prescribe these drugs.
This category includes drugs where funding has not yet been agreed.
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Refer to local guidance. |
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