Tablets 200mg

Oral suspension 40mg/ml

On advice of Microbiology only.

Treatment of Clostridium difficile infections (CDI) also known as C. difficile-associated diarrhoea (CDAD) in adults.

Fidaxomicin (Dificlir®) to be considered as an option for use following a first or second relapse. i.e. as second or third line therapy.
Fidaxomicin to also be considered for patients with severe CDI who are considered to be at high risk for recurrence as per the Public Health England Guidance. e.g. elderly patients with multiple comorbidities who are receiving concomitant antibiotics and those not responding to oral vancomycin.

Fidaxomicin is available via standard wholesaler, Alliance healthcare but is unlikely to be stocked in the majority of community pharmacies. Refer to ‘Fidaxomicin letter to community pharmacies’ for ordering details.